Package: methylclock
Type: Package
Title: Methylclock - DNA methylation-based clocks
Version: 1.16.0
Authors@R: c( person("Dolors", "Pelegri-Siso", , "dolors.pelegri@isglobal.org", 
                      role = c("aut", "cre"), 
                      comment = c(ORCID = "0000-0002-5993-3003")),
              person("Juan R.", "Gonzalez", ,"juanr.gonzalez@isglobal.org", 
                     role = c("aut"), 
                     comment = c(ORCID = "0000-0003-3267-2146"))
              )
Description: This package allows to estimate chronological and
        gestational DNA methylation (DNAm) age as well as biological
        age using different methylation clocks. Chronological DNAm age
        (in years) : Horvath's clock, Hannum's clock, BNN, Horvath's
        skin+blood clock, PedBE clock and Wu's clock. Gestational DNAm
        age : Knight's clock, Bohlin's clock, Mayne's clock and Lee's
        clocks. Biological DNAm clocks : Levine's clock and Telomere
        Length's clock.
biocViews: DNAMethylation, BiologicalQuestion, Preprocessing,
        StatisticalMethod, Normalization
License: MIT + file LICENSE
Depends: R (>= 4.1.0), methylclockData, devtools, quadprog
Imports: Rcpp (>= 1.0.6), ExperimentHub, dplyr, impute,
        PerformanceAnalytics, Biobase, ggpmisc, tidyverse, ggplot2,
        ggpubr, minfi, tibble, RPMM, stats, graphics, tidyr, gridExtra,
        preprocessCore, dynamicTreeCut, planet
Suggests: BiocStyle, knitr, GEOquery, rmarkdown
LinkingTo: Rcpp
Encoding: UTF-8
RoxygenNote: 7.1.2
URL: https://github.com/isglobal-brge/methylclock
BugReports: https://github.com/isglobal-brge/methylclock/issues
VignetteBuilder: knitr
Config/pak/sysreqs: cmake libfontconfig1-dev libfreetype6-dev
        libfribidi-dev git make libharfbuzz-dev libbz2-dev libgit2-dev
        libicu-dev libjpeg-dev liblzma-dev libpng-dev libtiff-dev
        libwebp-dev libxml2-dev libssl-dev libx11-dev xz-utils
        zlib1g-dev
Repository: https://bioc-release.r-universe.dev
Date/Publication: 2025-10-29 15:10:33 UTC
RemoteUrl: https://github.com/bioc/methylclock
RemoteRef: RELEASE_3_22
RemoteSha: 79b4e8bcbc78bc0e014d42c24f612afd83401082
NeedsCompilation: yes
Packaged: 2026-01-28 08:13:22 UTC; root
Author: Dolors Pelegri-Siso [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-5993-3003>),
  Juan R. Gonzalez [aut] (ORCID: <https://orcid.org/0000-0003-3267-2146>)
Maintainer: Dolors Pelegri-Siso <dolors.pelegri@isglobal.org>
Built: R 4.5.2; x86_64-w64-mingw32; 2026-01-28 08:16:35 UTC; windows
Archs: x64
