Package: G4SNVHunter
Type: Package
Title: Evaluating SNV-Induced Disruption of G-Quadruplex Structures
Version: 1.2.0
Authors@R: person(given = "Rongxin", 
                  family = "Zhang", 
                  email = "rongxinzhang@outlook.com", 
                  role = c("cre", "aut"),
                  comment = c('ORCID' = "0000-0002-1643-1185"))
Description: G-quadruplexes (G4s) are unique nucleic acid secondary
        structures predominantly found in guanine-rich regions and have
        been shown to be involved in various biological regulatory
        processes. G4SNVHunter is an R package designed to rapidly
        identify genomic sequences with G4-forming propensity and to
        accurately screen user-provided single nucleotide variants—as
        well as other small-scale variants such as indels and MNVs—for
        their potential to destabilize these structures. This allows
        researchers to then screen these critical variants for deeper
        study, digging into how they might influence biological
        functions—think gene regulation, for instance—by impairing G4
        formation propensity.
Encoding: UTF-8
LazyData: false
Depends: R (>= 4.3.0)
Imports: Biostrings, stats, GenomicRanges, IRanges, Rcpp, RcppRoll,
        data.table, Seqinfo, S4Vectors, ggplot2, cowplot, progress,
        ggseqlogo, viridis, ggpointdensity, tools,
        SummarizedExperiment, VariantAnnotation, dplyr, openxlsx,
        tidyr, magrittr, ggdensity
LinkingTo: Rcpp
RoxygenNote: 7.3.2
License: MIT + file LICENSE
Suggests: knitr, BiocStyle, rmarkdown, BiocManager,
        BSgenome.Hsapiens.UCSC.hg19, DT, rtracklayer, testthat (>=
        3.0.0), RBGL
VignetteBuilder: knitr
biocViews: Epigenetics, SNP
News: NEWS.md
URL: https://github.com/rongxinzh/G4SNVHunter
BugReports: https://github.com/rongxinzh/G4SNVHunter/issues
Config/testthat/edition: 3
Config/pak/sysreqs: make libbz2-dev libicu-dev liblzma-dev libpng-dev
        libxml2-dev libssl-dev xz-utils zlib1g-dev
Repository: https://bioc-release.r-universe.dev
Date/Publication: 2025-10-29 15:33:18 UTC
RemoteUrl: https://github.com/bioc/G4SNVHunter
RemoteRef: RELEASE_3_22
RemoteSha: 68a26803bf74668267bf0205c82559d73ce4d62d
NeedsCompilation: yes
Packaged: 2026-01-31 08:47:33 UTC; root
Author: Rongxin Zhang [cre, aut] (ORCID:
    <https://orcid.org/0000-0002-1643-1185>)
Maintainer: Rongxin Zhang <rongxinzhang@outlook.com>
Built: R 4.5.2; x86_64-w64-mingw32; 2026-01-31 08:52:10 UTC; windows
Archs: x64
