############################################################################## ############################################################################## ### ### Running command: ### ### chmod a+r OmnipathR -R && F:\biocbuild\bbs-3.22-bioc\R\bin\R.exe CMD build --keep-empty-dirs --no-resave-data OmnipathR ### ############################################################################## ############################################################################## * checking for file 'OmnipathR/DESCRIPTION' ... OK * preparing 'OmnipathR': * checking DESCRIPTION meta-information ... OK * installing the package to build vignettes * creating vignettes ... ERROR --- re-building 'bioc_workshop.Rmd' using rmarkdown [2025-06-27 20:53:05] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:05] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:05] [INFO] [OmnipathR] Initialized cache: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR`. [2025-06-27 20:53:05] [INFO] [OmnipathR] Package `OmnipathR` packaged: NA [2025-06-27 20:53:05] [INFO] [OmnipathR] Package `OmnipathR` date/publication: 2025-06-27 [2025-06-27 20:53:05] [INFO] [OmnipathR] Package `OmnipathR` built: R 4.5.1; ; 2025-06-28 00:51:40 UTC; windows [2025-06-27 20:53:05] [INFO] [OmnipathR] Package `OmnipathR` version: 3.17.0 [2025-06-27 20:53:05] [INFO] [OmnipathR] Package `OmnipathR` repository: Bioconductor 3.22 [2025-06-27 20:53:06] [INFO] [OmnipathR] Session info: [version=R version 4.5.1 (2025-06-13 ucrt); os=Windows Server 2022 x64 (build 20348); system=x86_64, mingw32; ui=RTerm; language=(EN); collate=C; ctype=English_United States.utf8; tz=America/New_York; date=2025-06-27; pandoc=2.7.3 @ C:/PROGRA~1/Pandoc/ (via rmarkdown); quarto=NA] [2025-06-27 20:53:06] [INFO] [OmnipathR] External libraries: [cairo=1.18.4; cairoFT=; pango=; png=1.6.48; jpeg=9.6; tiff=LIBTIFF, Version 4.7.0; tcl=8.6.16; curl=8.13.0; zlib=1.3.1; bzlib=1.0.8, 13-Jul-2019; xz=5.8.1; deflate=1.24; PCRE=10.45 2025-02-05; ICU=77.1; TRE=TRE 0.8.0 R_fixes (BSD); iconv=win_iconv; readline=; BLAS=; lapack=; lapack_version=3.12.1] [2025-06-27 20:53:07] [INFO] [OmnipathR] Loaded packages: backports 1.5.0(2024-05-23); BiocManager 1.30.26(2025-06-05); BiocStyle 2.37.0(2025-06-27); bit 4.6.0(2025-03-06); bit64 4.6.0-1(2025-01-16); blob 1.2.4(2023-03-17); bookdown 0.43(2025-04-15); bslib 0.9.0(2025-01-30); cachem 1.1.0(2024-05-16); cellranger 1.1.0(2016-07-27); checkmate 2.3.2(2024-07-29); chromote 0.5.1(2025-04-24); cli 3.6.5(2025-04-23); crayon 1.5.3(2024-06-20); curl 6.4.0(2025-06-22); DBI 1.2.3(2024-06-02); digest 0.6.37(2024-08-19); dplyr 1.1.4(2023-11-17); evaluate 1.0.4(2025-06-18); fastmap 1.2.0(2024-05-15); fs 1.6.6(2025-04-12); generics 0.1.4(2025-05-09); glue 1.8.0(2024-09-30); hms 1.1.3(2023-03-21); htmltools 0.5.8.1(2024-04-04); httr 1.4.7(2023-08-15); httr2 1.1.2(2025-03-26); igraph 2.1.4(2025-01-23); jquerylib 0.1.4(2021-04-26); jsonlite 2.0.0(2025-03-27); knitr 1.50(2025-03-16); later 1.4.2(2025-04-08); lifecycle 1.0.4(2023-11-07); logger 0.4.0(2024-10-22); lubridate 1.9.4(2024-12-08); magrittr 2.0.3(2022-03-30); memoise 2.0.1(2021-11-26); OmnipathR 3.17.0(2025-06-27); pillar 1.10.2(2025-04-05); pkgconfig 2.0.3(2019-09-22); prettyunits 1.2.0(2023-09-24); processx 3.8.6(2025-02-21); progress 1.2.3(2023-12-06); promises 1.3.3(2025-05-29); ps 1.9.1(2025-04-12); purrr 1.0.4(2025-02-05); R.methodsS3 1.8.2(2022-06-13); R.oo 1.27.1(2025-05-02); R.utils 2.13.0(2025-02-24); R6 2.6.1(2025-02-15); rappdirs 0.3.3(2021-01-31); Rcpp 1.0.14(2025-01-12); readr 2.1.5(2024-01-10); readxl 1.4.5(2025-03-07); rlang 1.1.6(2025-04-11); rmarkdown 2.29(2024-11-04); RSQLite 2.4.1(2025-06-08); rvest 1.0.4(2024-02-12); sass 0.4.10(2025-04-11); sessioninfo 1.2.3(2025-02-05); stringi 1.8.7(2025-03-27); stringr 1.5.1(2023-11-14); tibble 3.3.0(2025-06-08); tidyr 1.3.1(2024-01-24); tidyselect 1.2.1(2024-03-11); timechange 0.3.0(2024-01-18); tzdb 0.5.0(2025-03-15); vctrs 0.6.5(2023-12-01); websocket 1.4.4(2025-04-10); withr 3.0.2(2024-10-28); xfun 0.52(2025-04-02); XML 3.99-0.18(2025-01-01); xml2 1.3.8(2025-03-14); yaml 2.3.10(2024-07-26); zip 2.3.3(2025-05-13) [2025-06-27 20:53:07] [INFO] [OmnipathR] CURL: version: 8.14.1; headers: 8.14.1; ssl_version: (OpenSSL/3.5.0) Schannel; libz_version: 1.3; libssh_version: libssh2/1.11.0; libidn_version: NA; host: x86_64-w64-mingw32; protocols: dict, file, ftp, ftps, gopher, gophers, http, https, imap, imaps, ldap, ldaps, mqtt, pop3, pop3s, rtsp, scp, sftp, smb, smbs, smtp, smtps, telnet, tftp, ws, wss; ipv6: TRUE; http2: TRUE; idn: TRUE; url_parser: TRUE [2025-06-27 20:53:07] [TRACE] [OmnipathR] Running on a build server, wiping cache. [2025-06-27 20:53:07] [TRACE] [OmnipathR] Cache is at `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR`. [2025-06-27 20:53:07] [TRACE] [OmnipathR] Contains 1 files. [2025-06-27 20:53:07] [TRACE] [OmnipathR] Cache is locked: FALSE. [2025-06-27 20:53:07] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:07] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:07] [SUCCESS] [OmnipathR] Removing all cache contents from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR`. [2025-06-27 20:53:07] [TRACE] [OmnipathR] Pandoc version: `2.7.3`. [2025-06-27 20:53:07] [TRACE] [OmnipathR] Reading JSON from `F:/biocbuild/bbs-3.22-bioc/tmpdir/Rtmpuc68n8/Rinst1ee684f877db8/OmnipathR/db/db_def.json` (encoding: UTF-8). [2025-06-27 20:53:07] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:07] [TRACE] [OmnipathR] Reading JSON from `F:/biocbuild/bbs-3.22-bioc/tmpdir/Rtmpuc68n8/Rinst1ee684f877db8/OmnipathR/internal/magic_bytes.json` (encoding: UTF-8). [2025-06-27 20:53:07] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:07] [TRACE] [OmnipathR] Reading JSON from `F:/biocbuild/bbs-3.22-bioc/tmpdir/Rtmpuc68n8/Rinst1ee684f877db8/OmnipathR/internal/urls.json` (encoding: UTF-8). [2025-06-27 20:53:07] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:07] [TRACE] [OmnipathR] Reading JSON from `F:/biocbuild/bbs-3.22-bioc/tmpdir/Rtmpuc68n8/Rinst1ee684f877db8/OmnipathR/internal/id_types.json` (encoding: UTF-8). [2025-06-27 20:53:07] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:07] [TRACE] [OmnipathR] Cache locked: FALSE [2025-06-27 20:53:07] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:07] [TRACE] [OmnipathR] Arguments for OmniPath query: [dorothea_levels=[A,B],query_type=interactions] [2025-06-27 20:53:07] [INFO] [OmnipathR] Loading database `Ensembl and OMA organism names`. [2025-06-27 20:53:07] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:07] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:07] [INFO] [OmnipathR] Looking up in cache `https://www.ensembl.org/info/about/species.html`: key=7332486db7400730697234bad76ca0c8e4d00799, no version available. [2025-06-27 20:53:07] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:07] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:07] [INFO] [OmnipathR] Created new version for cache record 7332486db7400730697234bad76ca0c8e4d00799: version 1. [2025-06-27 20:53:07] [TRACE] [OmnipathR] Cache file path: C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/7332486db7400730697234bad76ca0c8e4d00799-1.html [2025-06-27 20:53:07] [INFO] [OmnipathR] Retrieving URL: `https://www.ensembl.org/info/about/species.html` [2025-06-27 20:53:07] [TRACE] [OmnipathR] Downloading by `httr2` in `download_base`. [2025-06-27 20:53:07] [TRACE] [OmnipathR] Attempt 1/3: `https://www.ensembl.org/info/about/species.html` [2025-06-27 20:53:07] [TRACE] [OmnipathR] Preparing httr2 request to URL `https://www.ensembl.org/info/about/species.html`. [2025-06-27 20:53:07] [TRACE] [OmnipathR] HTTP headers: [User-Agent=Mozilla/5.0 (X11; Linux x86_64; rv:134.0) Gecko/20100101 Firefox/134.0] [2025-06-27 20:53:07] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:07] [TRACE] [OmnipathR] HTTP headers: [User-Agent=Mozilla/5.0 (X11; Linux x86_64; rv:134.0) Gecko/20100101 Firefox/134.0] [2025-06-27 20:53:07] [TRACE] [OmnipathR] Sending HTTP request. [2025-06-27 20:53:08] [TRACE] [OmnipathR] HTTP 200 (OK) [2025-06-27 20:53:08] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:53:08] [TRACE] [OmnipathR] Downloaded 30.8 Kb in 0.848873s from www.ensembl.org (36.2 Kb/s); Redirect: 0s, DNS look up: 0.401697s, Connection: 0.483116s, Pretransfer: 0.586953s, First byte at: 0.746971s [2025-06-27 20:53:08] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Date: Sat, 28 Jun 2025 00:53:09 GMT; Content-Type: text/html; charset=utf-8; Content-Length: 31500; Connection: keep-alive; Server: Apache; Set-cookie: redirect_mirror=; path=/; expires=Mon, 01-Jan-2001 00:00:01 GMT; Set-cookie: redirect_mirror=no; path=/; expires=Sun, 29 Jun 2025 00:53:09 GMT; Set-cookie: ENSEMBL_HINX_SESSION=63c4f24835c595e50ee6323468ae56f50b2b479b26e10247dbb6a5ea; path=/; expires=Thu, 31-Dec-2037 23:59:59 GMT; HttpOnly; Set-cookie: redirect_mirror=; path=/; expires=Mon, 01-Jan-2001 00:00:01 GMT; Set-cookie: redirect_mirror=no; path=/; expires=Sun, 29 Jun 2025 00:53:09 GMT; Set-cookie: ENSEMBL_HINX_SESSION=63c4f24835c595e50ee6323468ae56f50b2b479b26e10247dbb6a5ea; path=/; expires=Thu, 31-Dec-2037 23:59:59 GMT; HttpOnly; Vary: Accept-Encoding; Content-Encoding: gzip; X-Frame-Options: SAMEORIGIN; Content-Security-Policy: frame-ancestors 'self'; X-NGINX-MACHINE: wp-p1m2-34.ebi.ac.uk [2025-06-27 20:53:08] [TRACE] [OmnipathR] Response headers: [Date=Sat, 28 Jun 2025 00:53:09 GMT,Content-Type=text/html; charset=utf-8,Content-Length=31500,Connection=keep-alive,Server=Apache,Set-cookie=redirect_mirror=; path=/; expires=Mon, 01-Jan-2001 00:00:01 GMT,Set-cookie=redirect_mirror=no; path=/; expires=Sun, 29 Jun 2025 00:53:09 GMT,Set-cookie=ENSEMBL_HINX_SESSION=63c4f24835c595e50ee6323468ae56f50b2b479b26e10247dbb6a5ea; path=/; expires=Thu, 31-Dec-2037 23:59:59 GMT; HttpOnly,Set-cookie=redirect_mirror=; path=/; expires=Mon, 01-Jan-2001 00:00:01 GMT,Set-cookie=redirect_mirror=no; path=/; expires=Sun, 29 Jun 2025 00:53:09 GMT,Set-cookie=ENSEMBL_HINX_SESSION=63c4f24835c595e50ee6323468ae56f50b2b479b26e10247dbb6a5ea; path=/; expires=Thu, 31-Dec-2037 23:59:59 GMT; HttpOnly,Vary=Accept-Encoding,Content-Encoding=gzip,X-Frame-Options=SAMEORIGIN,Content-Security-Policy=frame-ancestors 'self',X-NGINX-MACHINE=wp-p1m2-34.ebi.ac.uk] [2025-06-27 20:53:08] [INFO] [OmnipathR] Download ready [key=7332486db7400730697234bad76ca0c8e4d00799, version=1] [2025-06-27 20:53:08] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:08] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:08] [INFO] [OmnipathR] Cache item `7332486db7400730697234bad76ca0c8e4d00799` version 1: status changed from `unknown` to `ready`. [2025-06-27 20:53:09] [TRACE] [OmnipathR] Downloading by `generic_downloader`. [2025-06-27 20:53:09] [TRACE] [OmnipathR] Looking up in cache: `https://omabrowser.org/All/oma-species.txt`. [2025-06-27 20:53:09] [INFO] [OmnipathR] Cache record does not exist: `https://omabrowser.org/All/oma-species.txt` [2025-06-27 20:53:09] [TRACE] [OmnipathR] Could not find in cache, initiating download: `https://omabrowser.org/All/oma-species.txt`. [2025-06-27 20:53:09] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:09] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:09] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:09] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:09] [INFO] [OmnipathR] Cache item `30e690cbb55dfc63b5903ab337f34ffc2f4be397` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:09] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`. [2025-06-27 20:53:09] [INFO] [OmnipathR] Retrieving URL: `https://omabrowser.org/All/oma-species.txt` [2025-06-27 20:53:09] [TRACE] [OmnipathR] Attempt 1/3: `https://omabrowser.org/All/oma-species.txt` [2025-06-27 20:53:09] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:09] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:09] [TRACE] [OmnipathR] HTTP v2 GET: status 200. [2025-06-27 20:53:09] [TRACE] [OmnipathR] Downloaded 7.9 Kb in 0.590581s from omabrowser.org (13.4 Kb/s); Redirect: 0s, DNS look up: 0.282369s, Connection: 0.375366s, Pretransfer: 0.482604s, First byte at: 0.590153s [2025-06-27 20:53:09] [TRACE] [OmnipathR] HTTP headers: HTTP/2 200 ; date: Sat, 28 Jun 2025 00:53:10 GMT; server: nginx; strict-transport-security: max-age=31536000; includeSubDomains; content-type: text/plain; charset=UTF-8; last-modified: Wed, 20 Nov 2024 10:20:02 GMT; etag: W/"673db7d2-6517f"; access-control-allow-origin: *; content-encoding: gzip [2025-06-27 20:53:10] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`. [2025-06-27 20:53:10] [INFO] [OmnipathR] Download ready [key=30e690cbb55dfc63b5903ab337f34ffc2f4be397, version=1] [2025-06-27 20:53:10] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:10] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:10] [INFO] [OmnipathR] Cache item `30e690cbb55dfc63b5903ab337f34ffc2f4be397` version 1: status changed from `started` to `ready`. [2025-06-27 20:53:10] [INFO] [OmnipathR] Loaded database `Ensembl and OMA organism names`. [2025-06-27 20:53:10] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:10] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:10] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 20:53:10] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 20:53:10] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 20:53:10] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 20:53:10] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 20:53:10] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 20:53:10] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 20:53:10] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:10] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:11] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:53:11] [TRACE] [OmnipathR] Downloaded 31.7 Kb in 0.641317s from omnipathdb.org (49.4 Kb/s); Redirect: 0s, DNS look up: 0.192801s, Connection: 0.275468s, Pretransfer: 0.464796s, First byte at: 0.639705s [2025-06-27 20:53:11] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 00:53:12 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 01:53:12 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 20:53:12] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 20:53:12] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:12] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:12] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:12] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:12] [INFO] [OmnipathR] Cache item `8e1fed15bbe7704374f40d278e719e18b4a9d60f` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:12] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/8e1fed15bbe7704374f40d278e719e18b4a9d60f-1.rds`. [2025-06-27 20:53:13] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/8e1fed15bbe7704374f40d278e719e18b4a9d60f-1.rds`. [2025-06-27 20:53:13] [INFO] [OmnipathR] Download ready [key=8e1fed15bbe7704374f40d278e719e18b4a9d60f, version=1] [2025-06-27 20:53:13] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:13] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:13] [INFO] [OmnipathR] Cache item `8e1fed15bbe7704374f40d278e719e18b4a9d60f` version 1: status changed from `started` to `ready`. [2025-06-27 20:53:18] [SUCCESS] [OmnipathR] Downloaded 128218 interactions. [2025-06-27 20:53:23] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:23] [TRACE] [OmnipathR] Arguments for OmniPath query: [query_type=enzsub] [2025-06-27 20:53:23] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:23] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:23] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:23] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:23] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:23] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:23] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:23] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:23] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:23] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:23] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:23] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:53:23] [TRACE] [OmnipathR] Downloaded 31.7 Kb in 0.438665s from omnipathdb.org (72.2 Kb/s); Redirect: 0s, DNS look up: 0.004878s, Connection: 0.086941s, Pretransfer: 0.258719s, First byte at: 0.437739s [2025-06-27 20:53:23] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 00:53:24 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 01:53:24 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 20:53:24] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:24] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:24] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:24] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:24] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:24] [INFO] [OmnipathR] Cache item `a6f560033dff45b503a8016c14c974c4c04b5967` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:24] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/a6f560033dff45b503a8016c14c974c4c04b5967-1.rds`. [2025-06-27 20:53:25] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/a6f560033dff45b503a8016c14c974c4c04b5967-1.rds`. [2025-06-27 20:53:25] [INFO] [OmnipathR] Download ready [key=a6f560033dff45b503a8016c14c974c4c04b5967, version=1] [2025-06-27 20:53:25] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:25] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:25] [INFO] [OmnipathR] Cache item `a6f560033dff45b503a8016c14c974c4c04b5967` version 1: status changed from `started` to `ready`. [2025-06-27 20:53:27] [SUCCESS] [OmnipathR] Downloaded 43269 enzyme-substrate relationships. [2025-06-27 20:53:28] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:28] [TRACE] [OmnipathR] Arguments for OmniPath query: [query_type=interactions] [2025-06-27 20:53:28] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:28] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:28] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:28] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:28] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:28] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:28] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:28] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:28] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:28] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:28] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:28] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:53:28] [TRACE] [OmnipathR] Downloaded 31.7 Kb in 0.420602s from omnipathdb.org (75.3 Kb/s); Redirect: 0s, DNS look up: 0.001825s, Connection: 0.082397s, Pretransfer: 0.253597s, First byte at: 0.419896s [2025-06-27 20:53:28] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 00:53:29 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 01:53:29 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 20:53:29] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:29] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:29] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:30] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:30] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:30] [INFO] [OmnipathR] Cache item `a7b21d9d80a3837a50268df16d168128fc1c6ede` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:30] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/a7b21d9d80a3837a50268df16d168128fc1c6ede-1.rds`. [2025-06-27 20:53:30] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/a7b21d9d80a3837a50268df16d168128fc1c6ede-1.rds`. [2025-06-27 20:53:30] [INFO] [OmnipathR] Download ready [key=a7b21d9d80a3837a50268df16d168128fc1c6ede, version=1] [2025-06-27 20:53:30] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:30] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:30] [INFO] [OmnipathR] Cache item `a7b21d9d80a3837a50268df16d168128fc1c6ede` version 1: status changed from `started` to `ready`. [2025-06-27 20:53:33] [SUCCESS] [OmnipathR] Downloaded 81529 interactions. [2025-06-27 20:53:34] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:34] [TRACE] [OmnipathR] Arguments for OmniPath query: [query_type=complexes] [2025-06-27 20:53:34] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:34] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:34] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/complexes?license=academic` [2025-06-27 20:53:34] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/complexes?license=academic` [2025-06-27 20:53:34] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/complexes?license=academic` [2025-06-27 20:53:34] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/complexes?license=academic` [2025-06-27 20:53:34] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/complexes?license=academic` [2025-06-27 20:53:34] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/complexes?license=academic` [2025-06-27 20:53:34] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/complexes?license=academic` [2025-06-27 20:53:34] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:34] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:34] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:53:34] [TRACE] [OmnipathR] Downloaded 31.7 Kb in 0.43542s from omnipathdb.org (72.7 Kb/s); Redirect: 0s, DNS look up: 0.002112s, Connection: 0.091567s, Pretransfer: 0.261683s, First byte at: 0.434523s [2025-06-27 20:53:34] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 00:53:35 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 01:53:35 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 20:53:35] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/complexes?license=academic` [2025-06-27 20:53:35] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:35] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:35] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:35] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:35] [INFO] [OmnipathR] Cache item `d562abda40303226daf98b436df9cb85eaeb2ef3` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:35] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/d562abda40303226daf98b436df9cb85eaeb2ef3-1.rds`. [2025-06-27 20:53:36] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/d562abda40303226daf98b436df9cb85eaeb2ef3-1.rds`. [2025-06-27 20:53:36] [INFO] [OmnipathR] Download ready [key=d562abda40303226daf98b436df9cb85eaeb2ef3, version=1] [2025-06-27 20:53:36] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:36] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:36] [INFO] [OmnipathR] Cache item `d562abda40303226daf98b436df9cb85eaeb2ef3` version 1: status changed from `started` to `ready`. [2025-06-27 20:53:36] [SUCCESS] [OmnipathR] Downloaded 35459 protein complexes. [2025-06-27 20:53:36] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:36] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=UniProt_location,query_type=annotations] [2025-06-27 20:53:36] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:36] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:37] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 20:53:37] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:37] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 20:53:37] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 20:53:37] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 20:53:37] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 20:53:37] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 20:53:37] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 20:53:37] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 20:53:37] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:37] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:37] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:53:37] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.419844s from omnipathdb.org (37.3 Kb/s); Redirect: 0s, DNS look up: 0.002395s, Connection: 0.083895s, Pretransfer: 0.25718s, First byte at: 0.419275s [2025-06-27 20:53:37] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 00:53:38 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 01:53:38 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 20:53:38] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 20:53:38] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:38] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:38] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:38] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:38] [INFO] [OmnipathR] Cache item `f2e7cc5e753cd4e22d458171359dea86781ebae8` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:38] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/f2e7cc5e753cd4e22d458171359dea86781ebae8-1.rds`. [2025-06-27 20:53:38] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/f2e7cc5e753cd4e22d458171359dea86781ebae8-1.rds`. [2025-06-27 20:53:38] [INFO] [OmnipathR] Download ready [key=f2e7cc5e753cd4e22d458171359dea86781ebae8, version=1] [2025-06-27 20:53:38] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:38] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:38] [INFO] [OmnipathR] Cache item `f2e7cc5e753cd4e22d458171359dea86781ebae8` version 1: status changed from `started` to `ready`. [2025-06-27 20:53:38] [SUCCESS] [OmnipathR] Downloaded 76260 annotation records. [2025-06-27 20:53:39] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:39] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=Uniprot_location,query_type=annotations] [2025-06-27 20:53:39] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:39] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:39] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 20:53:39] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:39] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=Uniprot_location&license=academic` [2025-06-27 20:53:39] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=Uniprot_location&license=academic` [2025-06-27 20:53:39] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=Uniprot_location&license=academic` [2025-06-27 20:53:39] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=Uniprot_location&license=academic` [2025-06-27 20:53:39] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=Uniprot_location&license=academic` [2025-06-27 20:53:39] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=Uniprot_location&license=academic` [2025-06-27 20:53:39] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=Uniprot_location&license=academic` [2025-06-27 20:53:39] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:39] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:40] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:53:40] [TRACE] [OmnipathR] Downloaded 60 bytes in 0.332686s from omnipathdb.org (180 bytes/s); Redirect: 0s, DNS look up: 0.001804s, Connection: 0.081737s, Pretransfer: 0.251659s, First byte at: 0.332653s [2025-06-27 20:53:40] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 00:53:40 GMT; Content-Type: text/plain; charset=utf-8; Content-Length: 60; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 01:53:40 GMT; Cache-Control: public; X-Frame-Options: DENY [2025-06-27 20:53:40] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=Uniprot_location&license=academic` [2025-06-27 20:53:40] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:40] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:40] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:40] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:40] [INFO] [OmnipathR] Cache item `07dc3ca232cbc620ab6be7d21a3a41bfc7b2d3e1` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:40] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/07dc3ca232cbc620ab6be7d21a3a41bfc7b2d3e1-1.rds`. [2025-06-27 20:53:40] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/07dc3ca232cbc620ab6be7d21a3a41bfc7b2d3e1-1.rds`. [2025-06-27 20:53:40] [INFO] [OmnipathR] Download ready [key=07dc3ca232cbc620ab6be7d21a3a41bfc7b2d3e1, version=1] [2025-06-27 20:53:40] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:40] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:40] [INFO] [OmnipathR] Cache item `07dc3ca232cbc620ab6be7d21a3a41bfc7b2d3e1` version 1: status changed from `started` to `ready`. [2025-06-27 20:53:40] [SUCCESS] [OmnipathR] Downloaded 0 annotation records. [2025-06-27 20:53:40] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:40] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resuorces=UniProt_location,query_type=annotations] [2025-06-27 20:53:40] [FATAL] [OmnipathR] Downloading the entire annotations database is not allowed by default because of its huge size (>1GB). If you really want to do that, you find static files at https://archive.omnipathdb.org/. However we recommend to query a set of proteins or a few resources, depending on your interest. [2025-06-27 20:53:40] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:40] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=UniProt_location,query_type=annotations] [2025-06-27 20:53:40] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:40] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:41] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 20:53:41] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:41] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 20:53:41] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/f2e7cc5e753cd4e22d458171359dea86781ebae8-1.rds`. [2025-06-27 20:53:41] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 20:53:41] [SUCCESS] [OmnipathR] Loaded 76260 annotation records from cache. [2025-06-27 20:53:41] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:41] [TRACE] [OmnipathR] Arguments for OmniPath query: [proteins=[DLL1,MEIS2,PHOX2A,BACH1,KLF11,FOXO3,MEFV],wide=TRUE,resources=HPA_tissue,query_type=annotations] [2025-06-27 20:53:41] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:41] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:42] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 20:53:42] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:42] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=HPA_tissue&proteins=DLL1,MEIS2,PHOX2A,BACH1,KLF11,FOXO3,MEFV&license=academic` [2025-06-27 20:53:42] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=HPA_tissue&proteins=DLL1,MEIS2,PHOX2A,BACH1,KLF11,FOXO3,MEFV&license=academic` [2025-06-27 20:53:42] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=HPA_tissue&proteins=DLL1,MEIS2,PHOX2A,BACH1,KLF11,FOXO3,MEFV&license=academic` [2025-06-27 20:53:42] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=HPA_tissue&proteins=DLL1,MEIS2,PHOX2A,BACH1,KLF11,FOXO3,MEFV&license=academic` [2025-06-27 20:53:42] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=HPA_tissue&proteins=DLL1,MEIS2,PHOX2A,BACH1,KLF11,FOXO3,MEFV&license=academic` [2025-06-27 20:53:42] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=HPA_tissue&proteins=DLL1,MEIS2,PHOX2A,BACH1,KLF11,FOXO3,MEFV&license=academic` [2025-06-27 20:53:42] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=HPA_tissue&proteins=DLL1,MEIS2,PHOX2A,BACH1,KLF11,FOXO3,MEFV&license=academic` [2025-06-27 20:53:42] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:42] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:42] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:53:42] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.410588s from omnipathdb.org (38.2 Kb/s); Redirect: 0s, DNS look up: 0.001779s, Connection: 0.082012s, Pretransfer: 0.250173s, First byte at: 0.410014s [2025-06-27 20:53:42] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 00:53:43 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 01:53:43 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 20:53:43] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=HPA_tissue&proteins=DLL1,MEIS2,PHOX2A,BACH1,KLF11,FOXO3,MEFV&license=academic` [2025-06-27 20:53:43] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:43] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:43] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:43] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:43] [INFO] [OmnipathR] Cache item `92ead83eb455386da8cefb938ee16521d1b5f02d` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:43] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/92ead83eb455386da8cefb938ee16521d1b5f02d-1.rds`. [2025-06-27 20:53:43] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/92ead83eb455386da8cefb938ee16521d1b5f02d-1.rds`. [2025-06-27 20:53:43] [INFO] [OmnipathR] Download ready [key=92ead83eb455386da8cefb938ee16521d1b5f02d, version=1] [2025-06-27 20:53:43] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:43] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:43] [INFO] [OmnipathR] Cache item `92ead83eb455386da8cefb938ee16521d1b5f02d` version 1: status changed from `started` to `ready`. [2025-06-27 20:53:43] [SUCCESS] [OmnipathR] Downloaded 3870 annotation records. [2025-06-27 20:53:43] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:43] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=SignaLink_pathway,query_type=annotations] [2025-06-27 20:53:43] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:43] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:44] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 20:53:44] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:44] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 20:53:44] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 20:53:44] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 20:53:44] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 20:53:44] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 20:53:44] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 20:53:44] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 20:53:44] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:44] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:44] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:53:44] [TRACE] [OmnipathR] Downloaded 36.9 Kb in 0.432849s from omnipathdb.org (85.2 Kb/s); Redirect: 0s, DNS look up: 0.001829s, Connection: 0.081593s, Pretransfer: 0.268386s, First byte at: 0.431404s [2025-06-27 20:53:44] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 00:53:45 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 01:53:45 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 20:53:45] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 20:53:45] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:45] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:45] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:45] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:45] [INFO] [OmnipathR] Cache item `48f6d1c796292ce438ca19de4baf3e99ff368b61` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:45] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/48f6d1c796292ce438ca19de4baf3e99ff368b61-1.rds`. [2025-06-27 20:53:45] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/48f6d1c796292ce438ca19de4baf3e99ff368b61-1.rds`. [2025-06-27 20:53:45] [INFO] [OmnipathR] Download ready [key=48f6d1c796292ce438ca19de4baf3e99ff368b61, version=1] [2025-06-27 20:53:45] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:45] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:45] [INFO] [OmnipathR] Cache item `48f6d1c796292ce438ca19de4baf3e99ff368b61` version 1: status changed from `started` to `ready`. [2025-06-27 20:53:45] [SUCCESS] [OmnipathR] Downloaded 2487 annotation records. [2025-06-27 20:53:45] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:45] [TRACE] [OmnipathR] Arguments for OmniPath query: [datasets=omnipath] [2025-06-27 20:53:45] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:45] [TRACE] [OmnipathR] Arguments for OmniPath query: [datasets=omnipath,query_type=interactions] [2025-06-27 20:53:45] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:45] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:45] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:45] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/a7b21d9d80a3837a50268df16d168128fc1c6ede-1.rds`. [2025-06-27 20:53:45] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:53:48] [SUCCESS] [OmnipathR] Loaded 81529 interactions from cache. [2025-06-27 20:53:48] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:53:48] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=FALSE,resources=SignaLink_pathway,query_type=annotations] [2025-06-27 20:53:48] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:48] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:49] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 20:53:49] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:49] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 20:53:49] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/48f6d1c796292ce438ca19de4baf3e99ff368b61-1.rds`. [2025-06-27 20:53:49] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 20:53:49] [SUCCESS] [OmnipathR] Loaded 2487 annotation records from cache. [2025-06-27 20:53:49] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:49] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:49] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell?license=academic` [2025-06-27 20:53:49] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/intercell?license=academic` [2025-06-27 20:53:49] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/intercell?license=academic` [2025-06-27 20:53:49] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/intercell?license=academic` [2025-06-27 20:53:49] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/intercell?license=academic` [2025-06-27 20:53:49] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/intercell?license=academic` [2025-06-27 20:53:49] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/intercell?license=academic` [2025-06-27 20:53:49] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:49] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:49] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:53:49] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.409892s from omnipathdb.org (38.2 Kb/s); Redirect: 0s, DNS look up: 0.001777s, Connection: 0.081435s, Pretransfer: 0.250415s, First byte at: 0.409202s [2025-06-27 20:53:49] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 00:53:50 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 01:53:50 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 20:53:51] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/intercell?license=academic` [2025-06-27 20:53:51] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:51] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:51] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:51] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:51] [INFO] [OmnipathR] Cache item `88868f24833199a6a4a8e27980fa32cd50c1c600` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:51] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/88868f24833199a6a4a8e27980fa32cd50c1c600-1.rds`. [2025-06-27 20:53:53] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/88868f24833199a6a4a8e27980fa32cd50c1c600-1.rds`. [2025-06-27 20:53:53] [INFO] [OmnipathR] Download ready [key=88868f24833199a6a4a8e27980fa32cd50c1c600, version=1] [2025-06-27 20:53:53] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:53] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:53] [INFO] [OmnipathR] Cache item `88868f24833199a6a4a8e27980fa32cd50c1c600` version 1: status changed from `started` to `ready`. [2025-06-27 20:53:54] [SUCCESS] [OmnipathR] Downloaded 332447 intercellular communication role records. [2025-06-27 20:53:55] [TRACE] [OmnipathR] Bypassing call: `intercell_network(high_confidence = TRUE)`. [2025-06-27 20:53:55] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. [2025-06-27 20:53:55] [TRACE] [OmnipathR] Bypassing call: `intercell_network()`. [2025-06-27 20:53:55] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. [2025-06-27 20:53:55] [TRACE] [OmnipathR] Bypassing call: `filter_intercell_network(icn, ligand_receptor = TRUE, consensus_percentile = 30, `. [2025-06-27 20:53:55] [TRACE] [OmnipathR] Bypassing call: ` loc_consensus_percentile = 50, simplify = TRUE)`. [2025-06-27 20:53:55] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. [2025-06-27 20:53:56] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 20:53:56] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:56] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:53:56] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:53:56] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell_summary` [2025-06-27 20:53:56] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/intercell_summary` [2025-06-27 20:53:56] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/intercell_summary` [2025-06-27 20:53:56] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/intercell_summary` [2025-06-27 20:53:56] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/intercell_summary` [2025-06-27 20:53:56] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/intercell_summary` [2025-06-27 20:53:56] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/intercell_summary` [2025-06-27 20:53:56] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:56] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:56] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:53:56] [TRACE] [OmnipathR] Downloaded 8.7 Kb in 0.335863s from omnipathdb.org (26 Kb/s); Redirect: 0s, DNS look up: 0.001871s, Connection: 0.083181s, Pretransfer: 0.253918s, First byte at: 0.335535s [2025-06-27 20:53:56] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 00:53:57 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 01:53:57 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 20:53:57] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/intercell_summary` [2025-06-27 20:53:57] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:57] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:57] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:57] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:57] [INFO] [OmnipathR] Cache item `4609206529e6ae997a8de976fe1277b3b74cc032` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:57] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/4609206529e6ae997a8de976fe1277b3b74cc032-1.rds`. [2025-06-27 20:53:57] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/4609206529e6ae997a8de976fe1277b3b74cc032-1.rds`. [2025-06-27 20:53:57] [INFO] [OmnipathR] Download ready [key=4609206529e6ae997a8de976fe1277b3b74cc032, version=1] [2025-06-27 20:53:57] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:57] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:57] [INFO] [OmnipathR] Cache item `4609206529e6ae997a8de976fe1277b3b74cc032` version 1: status changed from `started` to `ready`. [2025-06-27 20:53:57] [SUCCESS] [OmnipathR] Downloaded 1098 records. [2025-06-27 20:53:57] [TRACE] [OmnipathR] ID translation table: from `uniprot` to `genesymbol`, using `uniprot`. [2025-06-27 20:53:57] [TRACE] [OmnipathR] Creating ID mapping table from `accession` to `gene_primary`, for organism 9606 (only reviewed: TRUE) [2025-06-27 20:53:57] [TRACE] [OmnipathR] Loading all UniProt records for organism 9606 (only reviewed: TRUE); fields: accession,gene_primary [2025-06-27 20:53:57] [TRACE] [OmnipathR] Downloading by `generic_downloader`. [2025-06-27 20:53:57] [TRACE] [OmnipathR] Looking up in cache: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:9606%20AND%20reviewed:true`. [2025-06-27 20:53:57] [INFO] [OmnipathR] Cache record does not exist: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:9606%20AND%20reviewed:true` [2025-06-27 20:53:57] [TRACE] [OmnipathR] Could not find in cache, initiating download: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:9606%20AND%20reviewed:true`. [2025-06-27 20:53:57] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:57] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:57] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:53:57] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:53:57] [INFO] [OmnipathR] Cache item `5edbb7050189a96382506b82b49b51a411621af7` version 1: status changed from `unknown` to `started`. [2025-06-27 20:53:57] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/5edbb7050189a96382506b82b49b51a411621af7-1.rds`. [2025-06-27 20:53:57] [INFO] [OmnipathR] Retrieving URL: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:9606%20AND%20reviewed:true` [2025-06-27 20:53:57] [TRACE] [OmnipathR] Attempt 1/3: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:9606%20AND%20reviewed:true` [2025-06-27 20:53:57] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:53:57] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:53:58] [TRACE] [OmnipathR] HTTP v2 GET: status 200. [2025-06-27 20:53:58] [TRACE] [OmnipathR] Downloaded 43 bytes in 0.548589s from rest.uniprot.org (78 bytes/s); Redirect: 0s, DNS look up: 0.038716s, Connection: 0.119876s, Pretransfer: 0.215934s, First byte at: 0.548407s [2025-06-27 20:53:58] [TRACE] [OmnipathR] HTTP headers: HTTP/2 200 ; vary: accept,accept-encoding,x-uniprot-release,x-api-deployment-date; vary: User-Agent; cache-control: public, max-age=43200; content-type: text/plain;format=tsv; content-encoding: gzip; access-control-allow-credentials: true; access-control-expose-headers: Link, X-Total-Results, X-UniProt-Release, X-UniProt-Release-Date, X-API-Deployment-Date; x-api-deployment-date: 18-June-2025; strict-transport-security: max-age=31536000; includeSubDomains; date: Sat, 28 Jun 2025 00:53:58 GMT; access-control-max-age: 1728000; x-uniprot-release: 2025_03; access-control-allow-origin: *; access-control-allow-methods: GET, PUT, POST, DELETE, PATCH, OPTIONS; access-control-allow-headers: DNT,Keep-Alive,User-Agent,X-Requested-With,If-Modified-Since,Cache-Control,Content-Type,Range,Authorization; x-uniprot-release-date: 18-June-2025 [2025-06-27 20:54:07] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/5edbb7050189a96382506b82b49b51a411621af7-1.rds`. [2025-06-27 20:54:07] [INFO] [OmnipathR] Download ready [key=5edbb7050189a96382506b82b49b51a411621af7, version=1] [2025-06-27 20:54:07] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:54:07] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:54:07] [INFO] [OmnipathR] Cache item `5edbb7050189a96382506b82b49b51a411621af7` version 1: status changed from `started` to `ready`. [2025-06-27 20:54:07] [SUCCESS] [OmnipathR] UniProt (rest.uniprot.org): downloaded 20420 records [2025-06-27 20:54:08] [TRACE] [OmnipathR] Translating complexes: 0 complexes in data. [2025-06-27 20:54:08] [TRACE] [OmnipathR] 0 complexes after removing the ones mapping to more than 1 items in target identifier space. [2025-06-27 20:54:08] [TRACE] [OmnipathR] Translated 0 complexes to 0. [2025-06-27 20:54:08] [TRACE] [OmnipathR] 4 rows before translation, 4 uniprot IDs in column `uniprot_id`. [2025-06-27 20:54:08] [TRACE] [OmnipathR] 4 rows after translation; translated 4 `uniprot` IDs in column `uniprot_id` to 4 `genesymbol` IDs in column `genesymbol`. [2025-06-27 20:54:08] [TRACE] [OmnipathR] Bypassing call: `go_ontology_download()`. [2025-06-27 20:54:08] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. [2025-06-27 20:54:08] [TRACE] [OmnipathR] Bypassing call: `relations_table_to_graph(go$rel_tbl_c2p)`. [2025-06-27 20:54:08] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. [2025-06-27 20:54:09] [TRACE] [OmnipathR] Bypassing call: `ontology_ensure_name("GO:0000022")`. [2025-06-27 20:54:09] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. --- finished re-building 'bioc_workshop.Rmd' --- re-building 'cosmos.Rmd' using rmarkdown [2025-06-27 20:54:12] [TRACE] [OmnipathR] Bypassing call: `chalmers_gem_raw()`. [2025-06-27 20:54:12] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. [2025-06-27 20:54:12] [TRACE] [OmnipathR] Bypassing call: `chalmers_gem()`. [2025-06-27 20:54:12] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. [2025-06-27 20:54:12] [TRACE] [OmnipathR] Bypassing call: `chalmers_gem_metabolites()`. [2025-06-27 20:54:12] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. [2025-06-27 20:54:13] [INFO] [OmnipathR] OmniPath network for COSMOS PKN; datasets: omnipath; resources: all; interaction types: post-translational (PPI); organism: Human. [2025-06-27 20:54:13] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:54:13] [TRACE] [OmnipathR] Arguments for OmniPath query: [organisms=9606,query_type=interactions] [2025-06-27 20:54:13] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:54:13] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:54:13] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:54:14] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/a7b21d9d80a3837a50268df16d168128fc1c6ede-1.rds`. [2025-06-27 20:54:14] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:54:17] [SUCCESS] [OmnipathR] Loaded 81529 interactions from cache. [2025-06-27 20:54:17] [TRACE] [OmnipathR] ID translation table: from `uniprot` to `genesymbol`, using Ensembl BioMart. [2025-06-27 20:54:17] [TRACE] [OmnipathR] Creating ID mapping table from `uniprotswissprot` to `external_gene_name`, for organism hsapiens [2025-06-27 20:54:17] [TRACE] [OmnipathR] BioMart query: [2025-06-27 20:54:17] [TRACE] [OmnipathR] Downloading by `generic_downloader`. [2025-06-27 20:54:17] [TRACE] [OmnipathR] Looking up in cache: `http://www.ensembl.org/biomart/martservice?query=%3C?xml%20version=%221.0%22%20encoding=%22UTF-8%22?%3E%0A%3C!DOCTYPE%20Query%3E%0A%3CQuery%20%20virtualSchemaName=%22default%22%20formatter=%22TSV%22%20header=%220%22%20uniqueRows=%220%22%20count=%22%22%20datasetConfigVersion=%220.6%22%20completionStamp=%221%22%20%3E%0A%20%20%20%20%3CDataset%20name=%22hsapiens_gene_ensembl%22%20interface=%22default%22%20%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22uniprotswissprot%22/%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22external_gene_name%22/%3E%0A%20%20%20%20%3C/Dataset%3E%0A%3C/Query%3E%0A`. [2025-06-27 20:54:17] [INFO] [OmnipathR] Cache record does not exist: `http://www.ensembl.org/biomart/martservice?query=%3C?xml%20version=%221.0%22%20encoding=%22UTF-8%22?%3E%0A%3C!DOCTYPE%20Query%3E%0A%3CQuery%20%20virtualSchemaName=%22default%22%20formatter=%22TSV%22%20header=%220%22%20uniqueRows=%220%22%20count=%22%22%20datasetConfigVersion=%220.6%22%20completionStamp=%221%22%20%3E%0A%20%20%20%20%3CDataset%20name=%22hsapiens_gene_ensembl%22%20interface=%22default%22%20%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22uniprotswissprot%22/%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22external_gene_name%22/%3E%0A%20%20%20%20%3C/Dataset%3E%0A%3C/Query%3E%0A` [2025-06-27 20:54:17] [TRACE] [OmnipathR] Could not find in cache, initiating download: `http://www.ensembl.org/biomart/martservice?query=%3C?xml%20version=%221.0%22%20encoding=%22UTF-8%22?%3E%0A%3C!DOCTYPE%20Query%3E%0A%3CQuery%20%20virtualSchemaName=%22default%22%20formatter=%22TSV%22%20header=%220%22%20uniqueRows=%220%22%20count=%22%22%20datasetConfigVersion=%220.6%22%20completionStamp=%221%22%20%3E%0A%20%20%20%20%3CDataset%20name=%22hsapiens_gene_ensembl%22%20interface=%22default%22%20%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22uniprotswissprot%22/%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22external_gene_name%22/%3E%0A%20%20%20%20%3C/Dataset%3E%0A%3C/Query%3E%0A`. [2025-06-27 20:54:17] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:54:17] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:54:17] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:54:17] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:54:17] [INFO] [OmnipathR] Cache item `d8282bd9b4260cbc5a0923f1eff00b1534d7f081` version 1: status changed from `unknown` to `started`. [2025-06-27 20:54:17] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/d8282bd9b4260cbc5a0923f1eff00b1534d7f081-1.rds`. [2025-06-27 20:54:17] [INFO] [OmnipathR] Retrieving URL: `http://www.ensembl.org/biomart/martservice?query=%3C?xml%20version=%221.0%22%20encoding=%22UTF-8%22?%3E%0A%3C!DOCTYPE%20Query%3E%0A%3CQuery%20%20virtualSchemaName=%22default%22%20formatter=%22TSV%22%20header=%220%22%20uniqueRows=%220%22%20count=%22%22%20datasetConfigVersion=%220.6%22%20completionStamp=%221%22%20%3E%0A%20%20%20%20%3CDataset%20name=%22hsapiens_gene_ensembl%22%20interface=%22default%22%20%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22uniprotswissprot%22/%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22external_gene_name%22/%3E%0A%20%20%20%20%3C/Dataset%3E%0A%3C/Query%3E%0A` [2025-06-27 20:54:17] [TRACE] [OmnipathR] Downloading by `httr2` in `download_base`. [2025-06-27 20:54:17] [TRACE] [OmnipathR] Attempt 1/3: `http://www.ensembl.org/biomart/martservice?query=%3C?xml%20version=%221.0%22%20encoding=%22UTF-8%22?%3E%0A%3C!DOCTYPE%20Query%3E%0A%3CQuery%20%20virtualSchemaName=%22default%22%20formatter=%22TSV%22%20header=%220%22%20uniqueRows=%220%22%20count=%22%22%20datasetConfigVersion=%220.6%22%20completionStamp=%221%22%20%3E%0A%20%20%20%20%3CDataset%20name=%22hsapiens_gene_ensembl%22%20interface=%22default%22%20%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22uniprotswissprot%22/%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22external_gene_name%22/%3E%0A%20%20%20%20%3C/Dataset%3E%0A%3C/Query%3E%0A` [2025-06-27 20:54:17] [TRACE] [OmnipathR] Preparing httr2 request to URL `http://www.ensembl.org/biomart/martservice?query=%3C?xml%20version=%221.0%22%20encoding=%22UTF-8%22?%3E%0A%3C!DOCTYPE%20Query%3E%0A%3CQuery%20%20virtualSchemaName=%22default%22%20formatter=%22TSV%22%20header=%220%22%20uniqueRows=%220%22%20count=%22%22%20datasetConfigVersion=%220.6%22%20completionStamp=%221%22%20%3E%0A%20%20%20%20%3CDataset%20name=%22hsapiens_gene_ensembl%22%20interface=%22default%22%20%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22uniprotswissprot%22/%3E%0A%20%20%20%20%20%20%20%20%3CAttribute%20name=%22external_gene_name%22/%3E%0A%20%20%20%20%3C/Dataset%3E%0A%3C/Query%3E%0A`. [2025-06-27 20:54:17] [TRACE] [OmnipathR] HTTP headers: [User-Agent=Mozilla/5.0 (X11; Linux x86_64; rv:134.0) Gecko/20100101 Firefox/134.0] [2025-06-27 20:54:17] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:54:17] [TRACE] [OmnipathR] HTTP headers: [User-Agent=Mozilla/5.0 (X11; Linux x86_64; rv:134.0) Gecko/20100101 Firefox/134.0] [2025-06-27 20:54:17] [TRACE] [OmnipathR] Sending HTTP request. [2025-06-27 20:54:18] [TRACE] [OmnipathR] HTTP 200 (OK) [2025-06-27 20:54:18] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:54:18] [TRACE] [OmnipathR] Downloaded 1014 bytes in 0.167868s from www.ensembl.org (5.9 Kb/s); Redirect: 0s, DNS look up: 0.002845s, Connection: 0.083762s, Pretransfer: 0.0839s, First byte at: 0.16774s [2025-06-27 20:54:18] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; X-GitHub-Request-Id: 778B:177D32:A7A2AD:A8B02E:685F0360; Server: GitHub.com; X-Cache-Hits: 50; Vary: Accept-Encoding; Cache-Control: no-cache, no-store, must-revalidate; x-proxy-cache: MISS; X-Cache: HIT; Content-Type: text/html; charset=utf-8; X-Fastly-Request-ID: 92db5d5cbf7ea7e71251a2dd709214dd716c414c; Content-Encoding: gzip; Date: Sat, 28 Jun 2025 00:54:18 GMT; Expires: 0; X-Served-By: cache-lcy-eglc8600025-LCY; Pragma: no-cache; X-Timer: S1751072059.794361,VS0,VE0; Access-Control-Allow-Origin: *; Accept-Ranges: bytes; ETag: W/"681dc811-8aa"; Via: 1.1 varnish; Connection: keep-alive; Age: 21; Content-Length: 1014 [2025-06-27 20:54:18] [TRACE] [OmnipathR] Response headers: [X-GitHub-Request-Id=778B:177D32:A7A2AD:A8B02E:685F0360,Server=GitHub.com,X-Cache-Hits=50,Vary=Accept-Encoding,Cache-Control=no-cache, no-store, must-revalidate,x-proxy-cache=MISS,X-Cache=HIT,Content-Type=text/html; charset=utf-8,X-Fastly-Request-ID=92db5d5cbf7ea7e71251a2dd709214dd716c414c,Content-Encoding=gzip,Date=Sat, 28 Jun 2025 00:54:18 GMT,Expires=0,X-Served-By=cache-lcy-eglc8600025-LCY,Pragma=no-cache,X-Timer=S1751072059.794361,VS0,VE0,Access-Control-Allow-Origin=*,Accept-Ranges=bytes,ETag=W/"681dc811-8aa",Via=1.1 varnish,Connection=keep-alive,Age=21,Content-Length=1014] [2025-06-27 20:54:18] [TRACE] [OmnipathR] Calling reader callback on response. [2025-06-27 20:54:18] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/d8282bd9b4260cbc5a0923f1eff00b1534d7f081-1.rds`. [2025-06-27 20:54:18] [INFO] [OmnipathR] Download ready [key=d8282bd9b4260cbc5a0923f1eff00b1534d7f081, version=1] [2025-06-27 20:54:18] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:54:18] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:54:18] [INFO] [OmnipathR] Cache item `d8282bd9b4260cbc5a0923f1eff00b1534d7f081` version 1: status changed from `started` to `ready`. [2025-06-27 20:54:18] [WARN] [OmnipathR] BioMart: missing success flag, data might be incomplete or contain error message! [2025-06-27 20:54:18] [WARN] [OmnipathR] [2025-06-27 20:54:18] [WARN] [OmnipathR] [2025-06-27 20:54:18] [WARN] [OmnipathR] Service unavailable [2025-06-27 20:54:18] [WARN] [OmnipathR] [2025-06-27 20:54:18] [WARN] [OmnipathR] [2025-06-27 20:54:18] [WARN] [OmnipathR] [2025-06-27 20:54:18] [WARN] [OmnipathR] [2025-06-27 20:54:18] [WARN] [OmnipathR] [2025-06-27 20:54:18] [WARN] [OmnipathR]
[2025-06-27 20:54:18] [WARN] [OmnipathR] ensembl-logo [2025-06-27 20:54:18] [WARN] [OmnipathR]
[2025-06-27 20:54:18] [WARN] [OmnipathR]
[2025-06-27 20:54:18] [WARN] [OmnipathR]

Server Status

[2025-06-27 20:54:18] [WARN] [OmnipathR]

[2025-06-27 20:54:18] [WARN] [OmnipathR] [!] [2025-06-27 20:54:18] [WARN] [OmnipathR] The Ensembl web service you requested is temporarily unavailable. [2025-06-27 20:54:18] [WARN] [OmnipathR] We are working to restore the service as soon as possible, and apologise for any inconvenience caused. [2025-06-27 20:54:18] [WARN] [OmnipathR]

[2025-06-27 20:54:18] [WARN] [OmnipathR]

For all enquiries, please contact our HelpDesk.

[2025-06-27 20:54:18] [WARN] [OmnipathR]
[2025-06-27 20:54:18] [WARN] [OmnipathR]

Ensembl mirrors

[2025-06-27 20:54:18] [WARN] [OmnipathR] We now also manage two mirrors of the Ensembl website, hosted in different regions of the Amazon cloud: [2025-06-27 20:54:18] [WARN] [OmnipathR] [2025-06-27 20:54:18] [WARN] [OmnipathR] These will be available while the main service is unavailable, although please note that some of the [2025-06-27 20:54:18] [WARN] [OmnipathR] facilities on these mirror may not be fully functional as they rely on resources hosted at our main [2025-06-27 20:54:18] [WARN] [OmnipathR] data centre. [2025-06-27 20:54:18] [WARN] [OmnipathR]
[2025-06-27 20:54:18] [WARN] [OmnipathR]
[2025-06-27 20:54:18] [WARN] [OmnipathR]
[2025-06-27 20:54:18] [WARN] [OmnipathR]

© 2025 EMBL-EBI

[2025-06-27 20:54:18] [WARN] [OmnipathR]
[2025-06-27 20:54:18] [WARN] [OmnipathR] [2025-06-27 20:54:18] [WARN] [OmnipathR] [2025-06-27 20:54:18] [SUCCESS] [OmnipathR] www.ensembl.org: downloaded 81 records Quitting from cosmos.Rmd:175-179 [omnipath] ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ NULL ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Error: processing vignette 'cosmos.Rmd' failed with diagnostics: The size of `nm` (2) must be compatible with the size of `x` (1). --- failed re-building 'cosmos.Rmd' --- re-building 'db_manager.Rmd' using rmarkdown [2025-06-27 20:54:19] [INFO] [OmnipathR] Loading database `UniProt-GeneSymbol table`. [2025-06-27 20:54:19] [TRACE] [OmnipathR] Creating ID mapping table from `accession` to `gene_primary`, for organism 9606 (only reviewed: TRUE) [2025-06-27 20:54:19] [TRACE] [OmnipathR] Loading all UniProt records for organism 9606 (only reviewed: TRUE); fields: accession,gene_primary [2025-06-27 20:54:19] [TRACE] [OmnipathR] Downloading by `generic_downloader`. [2025-06-27 20:54:19] [TRACE] [OmnipathR] Looking up in cache: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:9606%20AND%20reviewed:true`. [2025-06-27 20:54:19] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/5edbb7050189a96382506b82b49b51a411621af7-1.rds`. [2025-06-27 20:54:19] [SUCCESS] [OmnipathR] UniProt (rest.uniprot.org): loaded 20420 records from cache [2025-06-27 20:54:19] [INFO] [OmnipathR] Loaded database `UniProt-GeneSymbol table`. --- finished re-building 'db_manager.Rmd' --- re-building 'drug_targets.Rmd' using rmarkdown [2025-06-27 20:54:35] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:54:35] [TRACE] [OmnipathR] Arguments for OmniPath query: [datasets=omnipath] [2025-06-27 20:54:35] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:54:35] [TRACE] [OmnipathR] Arguments for OmniPath query: [datasets=omnipath,query_type=interactions] [2025-06-27 20:54:35] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:54:35] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:54:35] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:54:35] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/a7b21d9d80a3837a50268df16d168128fc1c6ede-1.rds`. [2025-06-27 20:54:35] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 20:54:39] [SUCCESS] [OmnipathR] Loaded 81529 interactions from cache. --- finished re-building 'drug_targets.Rmd' --- re-building 'extra_attrs.Rmd' using rmarkdown [2025-06-27 20:54:55] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 20:54:55] [TRACE] [OmnipathR] Arguments for OmniPath query: [fields=extra_attrs,query_type=interactions] [2025-06-27 20:54:55] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 20:54:55] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 20:54:55] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath,pathwayextra,kinaseextra,ligrecextra&organisms=9606&fields=extra_attrs,sources,references,curation_effort&license=academic` [2025-06-27 20:54:55] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath,pathwayextra,kinaseextra,ligrecextra&organisms=9606&fields=extra_attrs,sources,references,curation_effort&license=academic` [2025-06-27 20:54:55] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath,pathwayextra,kinaseextra,ligrecextra&organisms=9606&fields=extra_attrs,sources,references,curation_effort&license=academic` [2025-06-27 20:54:55] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath,pathwayextra,kinaseextra,ligrecextra&organisms=9606&fields=extra_attrs,sources,references,curation_effort&license=academic` [2025-06-27 20:54:55] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath,pathwayextra,kinaseextra,ligrecextra&organisms=9606&fields=extra_attrs,sources,references,curation_effort&license=academic` [2025-06-27 20:54:55] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath,pathwayextra,kinaseextra,ligrecextra&organisms=9606&fields=extra_attrs,sources,references,curation_effort&license=academic` [2025-06-27 20:54:55] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath,pathwayextra,kinaseextra,ligrecextra&organisms=9606&fields=extra_attrs,sources,references,curation_effort&license=academic` [2025-06-27 20:54:55] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 20:54:55] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 20:54:56] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 20:54:56] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.441891s from omnipathdb.org (35.5 Kb/s); Redirect: 0s, DNS look up: 0.002058s, Connection: 0.087929s, Pretransfer: 0.280581s, First byte at: 0.441425s [2025-06-27 20:54:56] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 00:54:56 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 01:54:56 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 20:54:57] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath,pathwayextra,kinaseextra,ligrecextra&organisms=9606&fields=extra_attrs,sources,references,curation_effort&license=academic` [2025-06-27 20:54:57] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:54:57] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:54:57] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:54:57] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:54:57] [INFO] [OmnipathR] Cache item `e9af339ce8e80bcec1a654822637ae3b71e035e2` version 1: status changed from `unknown` to `started`. [2025-06-27 20:54:57] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/e9af339ce8e80bcec1a654822637ae3b71e035e2-1.rds`. [2025-06-27 20:54:59] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/e9af339ce8e80bcec1a654822637ae3b71e035e2-1.rds`. [2025-06-27 20:54:59] [INFO] [OmnipathR] Download ready [key=e9af339ce8e80bcec1a654822637ae3b71e035e2, version=1] [2025-06-27 20:54:59] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 20:54:59] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 20:54:59] [INFO] [OmnipathR] Cache item `e9af339ce8e80bcec1a654822637ae3b71e035e2` version 1: status changed from `started` to `ready`. [2025-06-27 20:54:59] [TRACE] [OmnipathR] Converting JSON column `extra_attrs` to list. [2025-06-27 20:55:09] [SUCCESS] [OmnipathR] Downloaded 134282 interactions. [2025-06-27 21:04:12] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:12] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=UniProt_keyword,entity_types=protein,query_type=annotations] [2025-06-27 21:04:12] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:04:12] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:04:13] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:04:13] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:13] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=UniProt_keyword&entity_types=protein&license=academic` [2025-06-27 21:04:13] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=UniProt_keyword&entity_types=protein&license=academic` [2025-06-27 21:04:13] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=UniProt_keyword&entity_types=protein&license=academic` [2025-06-27 21:04:13] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=UniProt_keyword&entity_types=protein&license=academic` [2025-06-27 21:04:13] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=UniProt_keyword&entity_types=protein&license=academic` [2025-06-27 21:04:13] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=UniProt_keyword&entity_types=protein&license=academic` [2025-06-27 21:04:13] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=UniProt_keyword&entity_types=protein&license=academic` [2025-06-27 21:04:13] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:04:13] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:04:14] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:04:14] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.411933s from omnipathdb.org (38 Kb/s); Redirect: 0s, DNS look up: 0.002024s, Connection: 0.082349s, Pretransfer: 0.251704s, First byte at: 0.411445s [2025-06-27 21:04:14] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:04:14 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:04:14 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:04:15] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=UniProt_keyword&entity_types=protein&license=academic` [2025-06-27 21:04:15] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:15] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:15] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:15] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:15] [INFO] [OmnipathR] Cache item `0e2cc6ec8db9efe88661b213cfb09be72a32df7d` version 1: status changed from `unknown` to `started`. [2025-06-27 21:04:15] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/0e2cc6ec8db9efe88661b213cfb09be72a32df7d-1.rds`. [2025-06-27 21:04:16] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/0e2cc6ec8db9efe88661b213cfb09be72a32df7d-1.rds`. [2025-06-27 21:04:16] [INFO] [OmnipathR] Download ready [key=0e2cc6ec8db9efe88661b213cfb09be72a32df7d, version=1] [2025-06-27 21:04:16] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:16] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:16] [INFO] [OmnipathR] Cache item `0e2cc6ec8db9efe88661b213cfb09be72a32df7d` version 1: status changed from `started` to `ready`. [2025-06-27 21:04:16] [SUCCESS] [OmnipathR] Downloaded 205690 annotation records. [2025-06-27 21:04:17] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:17] [TRACE] [OmnipathR] Arguments for OmniPath query: [types=ubiquitination,query_type=enzsub] [2025-06-27 21:04:17] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:04:17] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:04:17] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic&types=ubiquitination` [2025-06-27 21:04:17] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic&types=ubiquitination` [2025-06-27 21:04:17] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic&types=ubiquitination` [2025-06-27 21:04:17] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic&types=ubiquitination` [2025-06-27 21:04:17] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic&types=ubiquitination` [2025-06-27 21:04:17] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic&types=ubiquitination` [2025-06-27 21:04:17] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic&types=ubiquitination` [2025-06-27 21:04:17] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:04:17] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:04:17] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:04:17] [TRACE] [OmnipathR] Downloaded 5.1 Kb in 0.345331s from omnipathdb.org (14.8 Kb/s); Redirect: 0s, DNS look up: 0.002156s, Connection: 0.098006s, Pretransfer: 0.265046s, First byte at: 0.345299s [2025-06-27 21:04:17] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:04:18 GMT; Content-Type: text/plain; charset=utf-8; Content-Length: 5219; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:04:18 GMT; Cache-Control: public; X-Frame-Options: DENY [2025-06-27 21:04:18] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic&types=ubiquitination` [2025-06-27 21:04:18] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:18] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:18] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:18] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:18] [INFO] [OmnipathR] Cache item `4525739875a94da1bbc48b8fada15795d234adcc` version 1: status changed from `unknown` to `started`. [2025-06-27 21:04:18] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/4525739875a94da1bbc48b8fada15795d234adcc-1.rds`. [2025-06-27 21:04:18] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/4525739875a94da1bbc48b8fada15795d234adcc-1.rds`. [2025-06-27 21:04:18] [INFO] [OmnipathR] Download ready [key=4525739875a94da1bbc48b8fada15795d234adcc, version=1] [2025-06-27 21:04:18] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:18] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:18] [INFO] [OmnipathR] Cache item `4525739875a94da1bbc48b8fada15795d234adcc` version 1: status changed from `started` to `ready`. [2025-06-27 21:04:18] [SUCCESS] [OmnipathR] Downloaded 70 enzyme-substrate relationships. --- finished re-building 'extra_attrs.Rmd' --- re-building 'nichenet.Rmd' using rmarkdown --- finished re-building 'nichenet.Rmd' --- re-building 'omnipath_intro.Rmd' using rmarkdown [2025-06-27 21:04:27] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:04:27] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:28] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:28] [TRACE] [OmnipathR] Arguments for OmniPath query: [resources=[SignaLink3,PhosphoSite,SIGNOR],datasets=omnipath] [2025-06-27 21:04:28] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:28] [TRACE] [OmnipathR] Arguments for OmniPath query: [resources=[SignaLink3,PhosphoSite,SIGNOR],datasets=omnipath,query_type=interactions] [2025-06-27 21:04:28] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:04:28] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:04:28] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:04:28] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:28] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=SignaLink3,PhosphoSite,SIGNOR&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:28] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&resources=SignaLink3,PhosphoSite,SIGNOR&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:28] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=SignaLink3,PhosphoSite,SIGNOR&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:28] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=SignaLink3,PhosphoSite,SIGNOR&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:28] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&resources=SignaLink3,PhosphoSite,SIGNOR&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:28] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&resources=SignaLink3,PhosphoSite,SIGNOR&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:28] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&resources=SignaLink3,PhosphoSite,SIGNOR&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:28] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:04:28] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:04:29] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:04:29] [TRACE] [OmnipathR] Downloaded 31.7 Kb in 0.436012s from omnipathdb.org (72.6 Kb/s); Redirect: 0s, DNS look up: 0.001904s, Connection: 0.100029s, Pretransfer: 0.270034s, First byte at: 0.43539s [2025-06-27 21:04:29] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:04:29 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:04:29 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:04:30] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&resources=SignaLink3,PhosphoSite,SIGNOR&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:30] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:30] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:30] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:30] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:30] [INFO] [OmnipathR] Cache item `5fc92405e5592146693f05f443dd80aec58163a5` version 1: status changed from `unknown` to `started`. [2025-06-27 21:04:30] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/5fc92405e5592146693f05f443dd80aec58163a5-1.rds`. [2025-06-27 21:04:31] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/5fc92405e5592146693f05f443dd80aec58163a5-1.rds`. [2025-06-27 21:04:31] [INFO] [OmnipathR] Download ready [key=5fc92405e5592146693f05f443dd80aec58163a5, version=1] [2025-06-27 21:04:31] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:31] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:31] [INFO] [OmnipathR] Cache item `5fc92405e5592146693f05f443dd80aec58163a5` version 1: status changed from `started` to `ready`. [2025-06-27 21:04:33] [SUCCESS] [OmnipathR] Downloaded 64485 interactions. [2025-06-27 21:04:44] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:44] [TRACE] [OmnipathR] Arguments for OmniPath query: [resources=[Wang,Lit-BM-17],organisms=10090,datasets=pathwayextra] [2025-06-27 21:04:44] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:44] [TRACE] [OmnipathR] Arguments for OmniPath query: [resources=[Wang,Lit-BM-17],organisms=10090,datasets=pathwayextra,query_type=interactions] [2025-06-27 21:04:44] [TRACE] [OmnipathR] Organism(s): 10090 [2025-06-27 21:04:44] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:04:45] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:04:45] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:45] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=Wang,Lit-BM-17&datasets=pathwayextra&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:45] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&resources=Wang,Lit-BM-17&datasets=pathwayextra&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:45] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=Wang,Lit-BM-17&datasets=pathwayextra&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:45] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=Wang,Lit-BM-17&datasets=pathwayextra&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:45] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&resources=Wang,Lit-BM-17&datasets=pathwayextra&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:45] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&resources=Wang,Lit-BM-17&datasets=pathwayextra&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:45] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&resources=Wang,Lit-BM-17&datasets=pathwayextra&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:45] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:04:45] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:04:45] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:04:45] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.411466s from omnipathdb.org (38.1 Kb/s); Redirect: 0s, DNS look up: 0.001868s, Connection: 0.082327s, Pretransfer: 0.251589s, First byte at: 0.411092s [2025-06-27 21:04:45] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:04:46 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:04:46 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:04:46] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&resources=Wang,Lit-BM-17&datasets=pathwayextra&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:47] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:47] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:47] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:47] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:47] [INFO] [OmnipathR] Cache item `3bebb563f03426a03a2bbe2548cea1de114c32e2` version 1: status changed from `unknown` to `started`. [2025-06-27 21:04:47] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/3bebb563f03426a03a2bbe2548cea1de114c32e2-1.rds`. [2025-06-27 21:04:47] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/3bebb563f03426a03a2bbe2548cea1de114c32e2-1.rds`. [2025-06-27 21:04:47] [INFO] [OmnipathR] Download ready [key=3bebb563f03426a03a2bbe2548cea1de114c32e2, version=1] [2025-06-27 21:04:47] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:47] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:47] [INFO] [OmnipathR] Cache item `3bebb563f03426a03a2bbe2548cea1de114c32e2` version 1: status changed from `started` to `ready`. [2025-06-27 21:04:48] [SUCCESS] [OmnipathR] Downloaded 39742 interactions. [2025-06-27 21:04:48] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:48] [TRACE] [OmnipathR] Arguments for OmniPath query: [resources=[PhosphoPoint,PhosphoSite],organisms=10116,datasets=kinaseextra] [2025-06-27 21:04:48] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:48] [TRACE] [OmnipathR] Arguments for OmniPath query: [resources=[PhosphoPoint,PhosphoSite],organisms=10116,datasets=kinaseextra,query_type=interactions] [2025-06-27 21:04:48] [TRACE] [OmnipathR] Organism(s): 10116 [2025-06-27 21:04:48] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:04:49] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:04:49] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:49] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=PhosphoPoint,PhosphoSite&datasets=kinaseextra&organisms=10116&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:49] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&resources=PhosphoPoint,PhosphoSite&datasets=kinaseextra&organisms=10116&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:49] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=PhosphoPoint,PhosphoSite&datasets=kinaseextra&organisms=10116&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:49] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=PhosphoPoint,PhosphoSite&datasets=kinaseextra&organisms=10116&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:49] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&resources=PhosphoPoint,PhosphoSite&datasets=kinaseextra&organisms=10116&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:49] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&resources=PhosphoPoint,PhosphoSite&datasets=kinaseextra&organisms=10116&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:49] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&resources=PhosphoPoint,PhosphoSite&datasets=kinaseextra&organisms=10116&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:49] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:04:49] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:04:49] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:04:49] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.407176s from omnipathdb.org (38.5 Kb/s); Redirect: 0s, DNS look up: 0.001972s, Connection: 0.081484s, Pretransfer: 0.248325s, First byte at: 0.406829s [2025-06-27 21:04:49] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:04:50 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:04:50 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:04:50] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&resources=PhosphoPoint,PhosphoSite&datasets=kinaseextra&organisms=10116&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:50] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:50] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:51] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:51] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:51] [INFO] [OmnipathR] Cache item `5cd314c4201dd53ec320a9f10d9b55c017d6143d` version 1: status changed from `unknown` to `started`. [2025-06-27 21:04:51] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/5cd314c4201dd53ec320a9f10d9b55c017d6143d-1.rds`. [2025-06-27 21:04:51] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/5cd314c4201dd53ec320a9f10d9b55c017d6143d-1.rds`. [2025-06-27 21:04:51] [INFO] [OmnipathR] Download ready [key=5cd314c4201dd53ec320a9f10d9b55c017d6143d, version=1] [2025-06-27 21:04:51] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:51] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:51] [INFO] [OmnipathR] Cache item `5cd314c4201dd53ec320a9f10d9b55c017d6143d` version 1: status changed from `started` to `ready`. [2025-06-27 21:04:51] [SUCCESS] [OmnipathR] Downloaded 6869 interactions. [2025-06-27 21:04:51] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:51] [TRACE] [OmnipathR] Arguments for OmniPath query: [resources=[iTALK,Baccin2019],organisms=9606,datasets=ligrecextra] [2025-06-27 21:04:51] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:51] [TRACE] [OmnipathR] Arguments for OmniPath query: [resources=[iTALK,Baccin2019],organisms=9606,datasets=ligrecextra,query_type=interactions] [2025-06-27 21:04:51] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:04:51] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:04:52] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:04:52] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:52] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=iTALK,Baccin2019&datasets=ligrecextra&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:52] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&resources=iTALK,Baccin2019&datasets=ligrecextra&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:52] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=iTALK,Baccin2019&datasets=ligrecextra&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:52] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=iTALK,Baccin2019&datasets=ligrecextra&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:52] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&resources=iTALK,Baccin2019&datasets=ligrecextra&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:52] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&resources=iTALK,Baccin2019&datasets=ligrecextra&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:52] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&resources=iTALK,Baccin2019&datasets=ligrecextra&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:52] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:04:52] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:04:52] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:04:52] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.413176s from omnipathdb.org (37.9 Kb/s); Redirect: 0s, DNS look up: 0.002178s, Connection: 0.082694s, Pretransfer: 0.251808s, First byte at: 0.412781s [2025-06-27 21:04:52] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:04:53 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:04:53 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:04:53] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&resources=iTALK,Baccin2019&datasets=ligrecextra&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:53] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:53] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:53] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:53] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:53] [INFO] [OmnipathR] Cache item `76b8ee6c20a073a1d42974b1a19964fdd2720dc5` version 1: status changed from `unknown` to `started`. [2025-06-27 21:04:53] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/76b8ee6c20a073a1d42974b1a19964fdd2720dc5-1.rds`. [2025-06-27 21:04:53] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/76b8ee6c20a073a1d42974b1a19964fdd2720dc5-1.rds`. [2025-06-27 21:04:53] [INFO] [OmnipathR] Download ready [key=76b8ee6c20a073a1d42974b1a19964fdd2720dc5, version=1] [2025-06-27 21:04:53] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:04:53] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:04:53] [INFO] [OmnipathR] Cache item `76b8ee6c20a073a1d42974b1a19964fdd2720dc5` version 1: status changed from `started` to `ready`. [2025-06-27 21:04:54] [SUCCESS] [OmnipathR] Downloaded 2834 interactions. [2025-06-27 21:04:54] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:54] [TRACE] [OmnipathR] Arguments for OmniPath query: [datasets=omnipath] [2025-06-27 21:04:54] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:54] [TRACE] [OmnipathR] Arguments for OmniPath query: [datasets=omnipath,query_type=interactions] [2025-06-27 21:04:54] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:04:54] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:04:54] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:54] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/a7b21d9d80a3837a50268df16d168128fc1c6ede-1.rds`. [2025-06-27 21:04:54] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:04:57] [SUCCESS] [OmnipathR] Loaded 81529 interactions from cache. [2025-06-27 21:04:58] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:04:58] [TRACE] [OmnipathR] Arguments for OmniPath query: [dorothea_levels=A,organisms=9606,query_type=interactions,datasets=dorothea] [2025-06-27 21:04:58] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:04:58] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:04:58] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 21:04:58] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 21:04:58] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 21:04:58] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 21:04:58] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 21:04:58] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 21:04:58] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 21:04:58] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:04:58] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:04:59] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:04:59] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.421317s from omnipathdb.org (37.2 Kb/s); Redirect: 0s, DNS look up: 0.001918s, Connection: 0.092245s, Pretransfer: 0.260857s, First byte at: 0.420983s [2025-06-27 21:04:59] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:04:59 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:04:59 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:05:00] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A&fields=sources,references,curation_effort,dorothea_level&license=academic` [2025-06-27 21:05:00] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:00] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:00] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:00] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:00] [INFO] [OmnipathR] Cache item `64f0eaeec4b695e11e6f2abe93eff9d2b0dc8bff` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:00] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/64f0eaeec4b695e11e6f2abe93eff9d2b0dc8bff-1.rds`. [2025-06-27 21:05:00] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/64f0eaeec4b695e11e6f2abe93eff9d2b0dc8bff-1.rds`. [2025-06-27 21:05:00] [INFO] [OmnipathR] Download ready [key=64f0eaeec4b695e11e6f2abe93eff9d2b0dc8bff, version=1] [2025-06-27 21:05:00] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:00] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:00] [INFO] [OmnipathR] Cache item `64f0eaeec4b695e11e6f2abe93eff9d2b0dc8bff` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:00] [SUCCESS] [OmnipathR] Downloaded 6127 interactions. [2025-06-27 21:05:00] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:00] [TRACE] [OmnipathR] Arguments for OmniPath query: [resources=[miR2Disease,miRDeathDB],query_type=interactions,datasets=mirnatarget] [2025-06-27 21:05:00] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:00] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:01] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:05:01] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:01] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=miR2Disease,miRDeathDB&datasets=mirnatarget&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:01] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&resources=miR2Disease,miRDeathDB&datasets=mirnatarget&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:01] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=miR2Disease,miRDeathDB&datasets=mirnatarget&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:01] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=miR2Disease,miRDeathDB&datasets=mirnatarget&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:01] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&resources=miR2Disease,miRDeathDB&datasets=mirnatarget&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:01] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&resources=miR2Disease,miRDeathDB&datasets=mirnatarget&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:01] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&resources=miR2Disease,miRDeathDB&datasets=mirnatarget&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:01] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:01] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:01] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:01] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.412545s from omnipathdb.org (38 Kb/s); Redirect: 0s, DNS look up: 0.00192s, Connection: 0.082427s, Pretransfer: 0.251484s, First byte at: 0.412142s [2025-06-27 21:05:01] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:05:02 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:05:02 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:05:02] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&resources=miR2Disease,miRDeathDB&datasets=mirnatarget&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:02] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:02] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:02] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:02] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:02] [INFO] [OmnipathR] Cache item `6fb27ffb4d0e53df1451b4f323099eab4e7b60ae` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:02] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/6fb27ffb4d0e53df1451b4f323099eab4e7b60ae-1.rds`. [2025-06-27 21:05:02] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/6fb27ffb4d0e53df1451b4f323099eab4e7b60ae-1.rds`. [2025-06-27 21:05:02] [INFO] [OmnipathR] Download ready [key=6fb27ffb4d0e53df1451b4f323099eab4e7b60ae, version=1] [2025-06-27 21:05:02] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:02] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:02] [INFO] [OmnipathR] Cache item `6fb27ffb4d0e53df1451b4f323099eab4e7b60ae` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:02] [SUCCESS] [OmnipathR] Downloaded 716 interactions. [2025-06-27 21:05:06] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:06] [TRACE] [OmnipathR] Arguments for OmniPath query: [sources=TRAMETINIB,query_type=interactions,datasets=small_molecule] [2025-06-27 21:05:06] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:06] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:06] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=small_molecule&organisms=9606&fields=sources,references,curation_effort&sources=TRAMETINIB&license=academic` [2025-06-27 21:05:06] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=small_molecule&organisms=9606&fields=sources,references,curation_effort&sources=TRAMETINIB&license=academic` [2025-06-27 21:05:06] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=small_molecule&organisms=9606&fields=sources,references,curation_effort&sources=TRAMETINIB&license=academic` [2025-06-27 21:05:06] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=small_molecule&organisms=9606&fields=sources,references,curation_effort&sources=TRAMETINIB&license=academic` [2025-06-27 21:05:06] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=small_molecule&organisms=9606&fields=sources,references,curation_effort&sources=TRAMETINIB&license=academic` [2025-06-27 21:05:06] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=small_molecule&organisms=9606&fields=sources,references,curation_effort&sources=TRAMETINIB&license=academic` [2025-06-27 21:05:06] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=small_molecule&organisms=9606&fields=sources,references,curation_effort&sources=TRAMETINIB&license=academic` [2025-06-27 21:05:06] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:06] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:06] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:06] [TRACE] [OmnipathR] Downloaded 2.2 Kb in 0.333717s from omnipathdb.org (6.5 Kb/s); Redirect: 0s, DNS look up: 0.002288s, Connection: 0.082424s, Pretransfer: 0.252785s, First byte at: 0.333688s [2025-06-27 21:05:06] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:05:07 GMT; Content-Type: text/plain; charset=utf-8; Content-Length: 2210; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:05:07 GMT; Cache-Control: public; X-Frame-Options: DENY [2025-06-27 21:05:07] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=small_molecule&organisms=9606&fields=sources,references,curation_effort&sources=TRAMETINIB&license=academic` [2025-06-27 21:05:07] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:07] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:07] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:07] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:07] [INFO] [OmnipathR] Cache item `c8829fb056a995e6935c4c5f23770852f8035247` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:07] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/c8829fb056a995e6935c4c5f23770852f8035247-1.rds`. [2025-06-27 21:05:07] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/c8829fb056a995e6935c4c5f23770852f8035247-1.rds`. [2025-06-27 21:05:07] [INFO] [OmnipathR] Download ready [key=c8829fb056a995e6935c4c5f23770852f8035247, version=1] [2025-06-27 21:05:07] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:07] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:07] [INFO] [OmnipathR] Cache item `c8829fb056a995e6935c4c5f23770852f8035247` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:07] [SUCCESS] [OmnipathR] Downloaded 32 interactions. [2025-06-27 21:05:08] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:05:08] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:08] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:08] [TRACE] [OmnipathR] Arguments for OmniPath query: [query_type=enzsub] [2025-06-27 21:05:08] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:08] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:08] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:08] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/a6f560033dff45b503a8016c14c974c4c04b5967-1.rds`. [2025-06-27 21:05:08] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/enzsub?genesymbols=yes&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:10] [SUCCESS] [OmnipathR] Loaded 43269 enzyme-substrate relationships from cache. [2025-06-27 21:05:10] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:10] [TRACE] [OmnipathR] Arguments for OmniPath query: [datasets=omnipath] [2025-06-27 21:05:10] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:10] [TRACE] [OmnipathR] Arguments for OmniPath query: [datasets=omnipath,query_type=interactions] [2025-06-27 21:05:10] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:10] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:10] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:10] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/a7b21d9d80a3837a50268df16d168128fc1c6ede-1.rds`. [2025-06-27 21:05:10] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:14] [SUCCESS] [OmnipathR] Loaded 81529 interactions from cache. [2025-06-27 21:05:15] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:15] [TRACE] [OmnipathR] Arguments for OmniPath query: [resources=[PhosphoSite,SIGNOR],organisms=10090,query_type=enzsub] [2025-06-27 21:05:15] [TRACE] [OmnipathR] Organism(s): 10090 [2025-06-27 21:05:15] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:16] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:05:16] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:16] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/enzsub?genesymbols=yes&resources=PhosphoSite,SIGNOR&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:16] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/enzsub?genesymbols=yes&resources=PhosphoSite,SIGNOR&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:16] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/enzsub?genesymbols=yes&resources=PhosphoSite,SIGNOR&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:16] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/enzsub?genesymbols=yes&resources=PhosphoSite,SIGNOR&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:16] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/enzsub?genesymbols=yes&resources=PhosphoSite,SIGNOR&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:16] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/enzsub?genesymbols=yes&resources=PhosphoSite,SIGNOR&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:16] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/enzsub?genesymbols=yes&resources=PhosphoSite,SIGNOR&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:16] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:16] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:16] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:16] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.419121s from omnipathdb.org (37.4 Kb/s); Redirect: 0s, DNS look up: 0.002023s, Connection: 0.083894s, Pretransfer: 0.255394s, First byte at: 0.418696s [2025-06-27 21:05:16] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:05:17 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:05:17 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:05:17] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/enzsub?genesymbols=yes&resources=PhosphoSite,SIGNOR&organisms=10090&fields=sources,references,curation_effort&license=academic` [2025-06-27 21:05:17] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:17] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:17] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:17] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:17] [INFO] [OmnipathR] Cache item `bce37a583e5f0da0390efc677c66c09007c26b09` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:17] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/bce37a583e5f0da0390efc677c66c09007c26b09-1.rds`. [2025-06-27 21:05:17] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/bce37a583e5f0da0390efc677c66c09007c26b09-1.rds`. [2025-06-27 21:05:18] [INFO] [OmnipathR] Download ready [key=bce37a583e5f0da0390efc677c66c09007c26b09, version=1] [2025-06-27 21:05:18] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:18] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:18] [INFO] [OmnipathR] Cache item `bce37a583e5f0da0390efc677c66c09007c26b09` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:18] [SUCCESS] [OmnipathR] Downloaded 17826 enzyme-substrate relationships. [2025-06-27 21:05:19] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:05:19] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:19] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:19] [TRACE] [OmnipathR] Arguments for OmniPath query: [resources=[CORUM,hu.MAP],query_type=complexes] [2025-06-27 21:05:19] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:19] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:19] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:05:19] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:20] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/complexes?resources=CORUM,hu.MAP&license=academic` [2025-06-27 21:05:20] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/complexes?resources=CORUM,hu.MAP&license=academic` [2025-06-27 21:05:20] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/complexes?resources=CORUM,hu.MAP&license=academic` [2025-06-27 21:05:20] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/complexes?resources=CORUM,hu.MAP&license=academic` [2025-06-27 21:05:20] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/complexes?resources=CORUM,hu.MAP&license=academic` [2025-06-27 21:05:20] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/complexes?resources=CORUM,hu.MAP&license=academic` [2025-06-27 21:05:20] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/complexes?resources=CORUM,hu.MAP&license=academic` [2025-06-27 21:05:20] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:20] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:20] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:20] [TRACE] [OmnipathR] Downloaded 31.7 Kb in 0.433875s from omnipathdb.org (73 Kb/s); Redirect: 0s, DNS look up: 0.002547s, Connection: 0.083085s, Pretransfer: 0.256878s, First byte at: 0.433243s [2025-06-27 21:05:20] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:05:21 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:05:21 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:05:21] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/complexes?resources=CORUM,hu.MAP&license=academic` [2025-06-27 21:05:21] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:21] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:21] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:21] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:21] [INFO] [OmnipathR] Cache item `d9d7d22ab08109542a41373aee9f37f4a6e4f1a5` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:21] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/d9d7d22ab08109542a41373aee9f37f4a6e4f1a5-1.rds`. [2025-06-27 21:05:21] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/d9d7d22ab08109542a41373aee9f37f4a6e4f1a5-1.rds`. [2025-06-27 21:05:21] [INFO] [OmnipathR] Download ready [key=d9d7d22ab08109542a41373aee9f37f4a6e4f1a5, version=1] [2025-06-27 21:05:21] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:21] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:21] [INFO] [OmnipathR] Cache item `d9d7d22ab08109542a41373aee9f37f4a6e4f1a5` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:21] [SUCCESS] [OmnipathR] Downloaded 7194 protein complexes. [2025-06-27 21:05:24] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:05:24] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:24] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:24] [TRACE] [OmnipathR] Arguments for OmniPath query: [proteins=[COMPLEX:NCAPD2_NCAPG_NCAPH_PARP1_SMC2_SMC4_XRCC1,COMPLEX:CCNA2_CDK2_LIG1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:CCNA2_CCNB1_CDK1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:MRE11_PARP1_RAD50_TERF2_TERF2IP_XRCC5_XRCC6,COMPLEX:TERF2_WRN,COMPLEX:CALR_DHX30_H2AX_H2BC26_HSPA5_NPM1_PARP1,COMPLEX:CTCF_H2AC18_H2AZ1_KPNA1_KPNA3_LMNA_NPM1_PARP1_TOP2A,COMPLEX:ACTB_HSPA4_MYH10_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CDK8_MED6_PARP1,COMPLEX:HSPA4_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,...],wide=FALSE,query_type=annotations] [2025-06-27 21:05:24] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:24] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:24] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?proteins=COMPLEX:NCAPD2_NCAPG_NCAPH_PARP1_SMC2_SMC4_XRCC1,COMPLEX:CCNA2_CDK2_LIG1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:CCNA2_CCNB1_CDK1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:MRE11_PARP1_RAD50_TERF2_TERF2IP_XRCC5_XRCC6,COMPLEX:TERF2_WRN,COMPLEX:CALR_DHX30_H2AX_H2BC26_HSPA5_NPM1_PARP1,COMPLEX:CTCF_H2AC18_H2AZ1_KPNA1_KPNA3_LMNA_NPM1_PARP1_TOP2A,COMPLEX:ACTB_HSPA4_MYH10_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CDK8_MED6_PARP1,COMPLEX:HSPA4_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CREBBP_H3C1_H4C8_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:CAMK2D_CREBBP_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:WRN_XRCC5_XRCC6,COMPLEX:NCOA6_PARP1_PRKDC_XRCC5_XRCC6,COMPLEX:PARP1_WRN_XRCC5_XRCC6,COMPLEX:FEN1_WRN,COMPLEX:LIG3_PARP1,COMPLEX:ATE1_BANF1_PARP1,COMPLEX:PAXX_WRN_XRCC6,COMPLEX:PAXX_PRKDC_WRN_XRCC6,COMPLEX:KIAA0930_KLHL11_PEF1_WRN&license=academic` [2025-06-27 21:05:24] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?proteins=COMPLEX:NCAPD2_NCAPG_NCAPH_PARP1_SMC2_SMC4_XRCC1,COMPLEX:CCNA2_CDK2_LIG1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:CCNA2_CCNB1_CDK1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:MRE11_PARP1_RAD50_TERF2_TERF2IP_XRCC5_XRCC6,COMPLEX:TERF2_WRN,COMPLEX:CALR_DHX30_H2AX_H2BC26_HSPA5_NPM1_PARP1,COMPLEX:CTCF_H2AC18_H2AZ1_KPNA1_KPNA3_LMNA_NPM1_PARP1_TOP2A,COMPLEX:ACTB_HSPA4_MYH10_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CDK8_MED6_PARP1,COMPLEX:HSPA4_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CREBBP_H3C1_H4C8_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:CAMK2D_CREBBP_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:WRN_XRCC5_XRCC6,COMPLEX:NCOA6_PARP1_PRKDC_XRCC5_XRCC6,COMPLEX:PARP1_WRN_XRCC5_XRCC6,COMPLEX:FEN1_WRN,COMPLEX:LIG3_PARP1,COMPLEX:ATE1_BANF1_PARP1,COMPLEX:PAXX_WRN_XRCC6,COMPLEX:PAXX_PRKDC_WRN_XRCC6,COMPLEX:KIAA0930_KLHL11_PEF1_WRN&license=academic` [2025-06-27 21:05:24] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?proteins=COMPLEX:NCAPD2_NCAPG_NCAPH_PARP1_SMC2_SMC4_XRCC1,COMPLEX:CCNA2_CDK2_LIG1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:CCNA2_CCNB1_CDK1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:MRE11_PARP1_RAD50_TERF2_TERF2IP_XRCC5_XRCC6,COMPLEX:TERF2_WRN,COMPLEX:CALR_DHX30_H2AX_H2BC26_HSPA5_NPM1_PARP1,COMPLEX:CTCF_H2AC18_H2AZ1_KPNA1_KPNA3_LMNA_NPM1_PARP1_TOP2A,COMPLEX:ACTB_HSPA4_MYH10_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CDK8_MED6_PARP1,COMPLEX:HSPA4_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CREBBP_H3C1_H4C8_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:CAMK2D_CREBBP_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:WRN_XRCC5_XRCC6,COMPLEX:NCOA6_PARP1_PRKDC_XRCC5_XRCC6,COMPLEX:PARP1_WRN_XRCC5_XRCC6,COMPLEX:FEN1_WRN,COMPLEX:LIG3_PARP1,COMPLEX:ATE1_BANF1_PARP1,COMPLEX:PAXX_WRN_XRCC6,COMPLEX:PAXX_PRKDC_WRN_XRCC6,COMPLEX:KIAA0930_KLHL11_PEF1_WRN&license=academic` [2025-06-27 21:05:24] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?proteins=COMPLEX:NCAPD2_NCAPG_NCAPH_PARP1_SMC2_SMC4_XRCC1,COMPLEX:CCNA2_CDK2_LIG1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:CCNA2_CCNB1_CDK1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:MRE11_PARP1_RAD50_TERF2_TERF2IP_XRCC5_XRCC6,COMPLEX:TERF2_WRN,COMPLEX:CALR_DHX30_H2AX_H2BC26_HSPA5_NPM1_PARP1,COMPLEX:CTCF_H2AC18_H2AZ1_KPNA1_KPNA3_LMNA_NPM1_PARP1_TOP2A,COMPLEX:ACTB_HSPA4_MYH10_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CDK8_MED6_PARP1,COMPLEX:HSPA4_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CREBBP_H3C1_H4C8_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:CAMK2D_CREBBP_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:WRN_XRCC5_XRCC6,COMPLEX:NCOA6_PARP1_PRKDC_XRCC5_XRCC6,COMPLEX:PARP1_WRN_XRCC5_XRCC6,COMPLEX:FEN1_WRN,COMPLEX:LIG3_PARP1,COMPLEX:ATE1_BANF1_PARP1,COMPLEX:PAXX_WRN_XRCC6,COMPLEX:PAXX_PRKDC_WRN_XRCC6,COMPLEX:KIAA0930_KLHL11_PEF1_WRN&license=academic` [2025-06-27 21:05:24] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?proteins=COMPLEX:NCAPD2_NCAPG_NCAPH_PARP1_SMC2_SMC4_XRCC1,COMPLEX:CCNA2_CDK2_LIG1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:CCNA2_CCNB1_CDK1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:MRE11_PARP1_RAD50_TERF2_TERF2IP_XRCC5_XRCC6,COMPLEX:TERF2_WRN,COMPLEX:CALR_DHX30_H2AX_H2BC26_HSPA5_NPM1_PARP1,COMPLEX:CTCF_H2AC18_H2AZ1_KPNA1_KPNA3_LMNA_NPM1_PARP1_TOP2A,COMPLEX:ACTB_HSPA4_MYH10_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CDK8_MED6_PARP1,COMPLEX:HSPA4_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CREBBP_H3C1_H4C8_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:CAMK2D_CREBBP_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:WRN_XRCC5_XRCC6,COMPLEX:NCOA6_PARP1_PRKDC_XRCC5_XRCC6,COMPLEX:PARP1_WRN_XRCC5_XRCC6,COMPLEX:FEN1_WRN,COMPLEX:LIG3_PARP1,COMPLEX:ATE1_BANF1_PARP1,COMPLEX:PAXX_WRN_XRCC6,COMPLEX:PAXX_PRKDC_WRN_XRCC6,COMPLEX:KIAA0930_KLHL11_PEF1_WRN&license=academic` [2025-06-27 21:05:24] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?proteins=COMPLEX:NCAPD2_NCAPG_NCAPH_PARP1_SMC2_SMC4_XRCC1,COMPLEX:CCNA2_CDK2_LIG1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:CCNA2_CCNB1_CDK1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:MRE11_PARP1_RAD50_TERF2_TERF2IP_XRCC5_XRCC6,COMPLEX:TERF2_WRN,COMPLEX:CALR_DHX30_H2AX_H2BC26_HSPA5_NPM1_PARP1,COMPLEX:CTCF_H2AC18_H2AZ1_KPNA1_KPNA3_LMNA_NPM1_PARP1_TOP2A,COMPLEX:ACTB_HSPA4_MYH10_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CDK8_MED6_PARP1,COMPLEX:HSPA4_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CREBBP_H3C1_H4C8_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:CAMK2D_CREBBP_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:WRN_XRCC5_XRCC6,COMPLEX:NCOA6_PARP1_PRKDC_XRCC5_XRCC6,COMPLEX:PARP1_WRN_XRCC5_XRCC6,COMPLEX:FEN1_WRN,COMPLEX:LIG3_PARP1,COMPLEX:ATE1_BANF1_PARP1,COMPLEX:PAXX_WRN_XRCC6,COMPLEX:PAXX_PRKDC_WRN_XRCC6,COMPLEX:KIAA0930_KLHL11_PEF1_WRN&license=academic` [2025-06-27 21:05:24] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?proteins=COMPLEX:NCAPD2_NCAPG_NCAPH_PARP1_SMC2_SMC4_XRCC1,COMPLEX:CCNA2_CDK2_LIG1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:CCNA2_CCNB1_CDK1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:MRE11_PARP1_RAD50_TERF2_TERF2IP_XRCC5_XRCC6,COMPLEX:TERF2_WRN,COMPLEX:CALR_DHX30_H2AX_H2BC26_HSPA5_NPM1_PARP1,COMPLEX:CTCF_H2AC18_H2AZ1_KPNA1_KPNA3_LMNA_NPM1_PARP1_TOP2A,COMPLEX:ACTB_HSPA4_MYH10_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CDK8_MED6_PARP1,COMPLEX:HSPA4_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CREBBP_H3C1_H4C8_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:CAMK2D_CREBBP_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:WRN_XRCC5_XRCC6,COMPLEX:NCOA6_PARP1_PRKDC_XRCC5_XRCC6,COMPLEX:PARP1_WRN_XRCC5_XRCC6,COMPLEX:FEN1_WRN,COMPLEX:LIG3_PARP1,COMPLEX:ATE1_BANF1_PARP1,COMPLEX:PAXX_WRN_XRCC6,COMPLEX:PAXX_PRKDC_WRN_XRCC6,COMPLEX:KIAA0930_KLHL11_PEF1_WRN&license=academic` [2025-06-27 21:05:24] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:24] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:24] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:24] [TRACE] [OmnipathR] Downloaded 15 Kb in 0.422565s from omnipathdb.org (35.4 Kb/s); Redirect: 0s, DNS look up: 0.002046s, Connection: 0.090489s, Pretransfer: 0.25894s, First byte at: 0.421979s [2025-06-27 21:05:24] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:05:25 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:05:25 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:05:25] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?proteins=COMPLEX:NCAPD2_NCAPG_NCAPH_PARP1_SMC2_SMC4_XRCC1,COMPLEX:CCNA2_CDK2_LIG1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:CCNA2_CCNB1_CDK1_PARP1_POLA1_POLD1_POLE_RFC1_RFC2_RPA1_RPA2_RPA3_TOP1,COMPLEX:MRE11_PARP1_RAD50_TERF2_TERF2IP_XRCC5_XRCC6,COMPLEX:TERF2_WRN,COMPLEX:CALR_DHX30_H2AX_H2BC26_HSPA5_NPM1_PARP1,COMPLEX:CTCF_H2AC18_H2AZ1_KPNA1_KPNA3_LMNA_NPM1_PARP1_TOP2A,COMPLEX:ACTB_HSPA4_MYH10_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CDK8_MED6_PARP1,COMPLEX:HSPA4_NCL_NONO_NPM1_PARP1_RAD50_TLE1_TOP2B,COMPLEX:CREBBP_H3C1_H4C8_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:CAMK2D_CREBBP_HES1_KAT2B_NONO_PARP1_POLR2A_SRC,COMPLEX:WRN_XRCC5_XRCC6,COMPLEX:NCOA6_PARP1_PRKDC_XRCC5_XRCC6,COMPLEX:PARP1_WRN_XRCC5_XRCC6,COMPLEX:FEN1_WRN,COMPLEX:LIG3_PARP1,COMPLEX:ATE1_BANF1_PARP1,COMPLEX:PAXX_WRN_XRCC6,COMPLEX:PAXX_PRKDC_WRN_XRCC6,COMPLEX:KIAA0930_KLHL11_PEF1_WRN&license=academic` [2025-06-27 21:05:25] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:25] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:25] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:25] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:25] [INFO] [OmnipathR] Cache item `e666cdf8b0e6e846fc6eb9319c9261ea08f0995d` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:25] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/e666cdf8b0e6e846fc6eb9319c9261ea08f0995d-1.rds`. [2025-06-27 21:05:25] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/e666cdf8b0e6e846fc6eb9319c9261ea08f0995d-1.rds`. [2025-06-27 21:05:25] [INFO] [OmnipathR] Download ready [key=e666cdf8b0e6e846fc6eb9319c9261ea08f0995d, version=1] [2025-06-27 21:05:25] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:25] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:25] [INFO] [OmnipathR] Cache item `e666cdf8b0e6e846fc6eb9319c9261ea08f0995d` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:25] [SUCCESS] [OmnipathR] Downloaded 1237 annotation records. [2025-06-27 21:05:25] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:25] [TRACE] [OmnipathR] Arguments for OmniPath query: [proteins=[NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,...],wide=FALSE,resources=NetPath,query_type=annotations] [2025-06-27 21:05:25] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:25] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:26] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:05:26] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:26] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=NetPath&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:26] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=NetPath&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:26] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=NetPath&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:26] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=NetPath&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:26] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=NetPath&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:26] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=NetPath&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:26] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=NetPath&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:26] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:26] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:26] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:26] [TRACE] [OmnipathR] Downloaded 5.8 Kb in 0.342469s from omnipathdb.org (17 Kb/s); Redirect: 0s, DNS look up: 0.00197s, Connection: 0.081934s, Pretransfer: 0.250075s, First byte at: 0.342418s [2025-06-27 21:05:26] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:05:27 GMT; Content-Type: text/plain; charset=utf-8; Content-Length: 5949; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:05:27 GMT; Cache-Control: public; X-Frame-Options: DENY [2025-06-27 21:05:27] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=NetPath&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:27] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:27] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:27] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:27] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:27] [INFO] [OmnipathR] Cache item `72a8d891c5e3f648f5330031c8382decd1c9ce51` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:27] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/72a8d891c5e3f648f5330031c8382decd1c9ce51-1.rds`. [2025-06-27 21:05:27] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/72a8d891c5e3f648f5330031c8382decd1c9ce51-1.rds`. [2025-06-27 21:05:27] [INFO] [OmnipathR] Download ready [key=72a8d891c5e3f648f5330031c8382decd1c9ce51, version=1] [2025-06-27 21:05:27] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:27] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:27] [INFO] [OmnipathR] Cache item `72a8d891c5e3f648f5330031c8382decd1c9ce51` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:27] [SUCCESS] [OmnipathR] Downloaded 86 annotation records. [2025-06-27 21:05:27] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:27] [TRACE] [OmnipathR] Arguments for OmniPath query: [proteins=[NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,...],wide=FALSE,resources=ComPPI,query_type=annotations] [2025-06-27 21:05:27] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:27] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:28] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:05:28] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:28] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=ComPPI&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:28] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=ComPPI&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:28] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=ComPPI&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:28] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=ComPPI&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:28] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=ComPPI&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:28] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=ComPPI&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:28] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=ComPPI&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:28] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:28] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:28] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:28] [TRACE] [OmnipathR] Downloaded 3.8 Kb in 0.329475s from omnipathdb.org (11.4 Kb/s); Redirect: 0s, DNS look up: 0.002056s, Connection: 0.081749s, Pretransfer: 0.248912s, First byte at: 0.329276s [2025-06-27 21:05:28] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:05:29 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:05:29 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:05:29] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=ComPPI&proteins=NCAPD2,NCAPG,NCAPH,PARP1,SMC2,SMC4,XRCC1,CCNA2,CDK2,LIG1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,CCNA2,CCNB1,CDK1,PARP1,POLA1,POLD1,POLE,RFC1,RFC2,RPA1,RPA2,RPA3,TOP1,MRE11,PARP1,RAD50,TERF2,TERF2IP,XRCC5,XRCC6,TERF2,WRN,CALR,DHX30,H2AX,H2BC26,HSPA5,NPM1,PARP1,CTCF,H2AC18,H2AZ1,KPNA1,KPNA3,LMNA,NPM1,PARP1,TOP2A,ACTB,HSPA4,MYH10,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CDK8,MED6,PARP1,HSPA4,NCL,NONO,NPM1,PARP1,RAD50,TLE1,TOP2B,CREBBP,H3C1,H4C8,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,CAMK2D,CREBBP,HES1,KAT2B,NONO,PARP1,POLR2A,SRC,WRN,XRCC5,XRCC6,NCOA6,PARP1,PRKDC,XRCC5,XRCC6,PARP1,WRN,XRCC5,XRCC6,FEN1,WRN,LIG3,PARP1,ATE1,BANF1,PARP1,PAXX,WRN,XRCC6,PAXX,PRKDC,WRN,XRCC6,KIAA0930,KLHL11,PEF1,WRN&license=academic` [2025-06-27 21:05:29] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:29] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:29] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:29] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:29] [INFO] [OmnipathR] Cache item `ddeb1f70cb112e394ecedc8a102cdde6b3254ab7` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:29] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/ddeb1f70cb112e394ecedc8a102cdde6b3254ab7-1.rds`. [2025-06-27 21:05:29] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/ddeb1f70cb112e394ecedc8a102cdde6b3254ab7-1.rds`. [2025-06-27 21:05:29] [INFO] [OmnipathR] Download ready [key=ddeb1f70cb112e394ecedc8a102cdde6b3254ab7, version=1] [2025-06-27 21:05:29] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:29] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:29] [INFO] [OmnipathR] Cache item `ddeb1f70cb112e394ecedc8a102cdde6b3254ab7` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:29] [SUCCESS] [OmnipathR] Downloaded 424 annotation records. [2025-06-27 21:05:30] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:30] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=SignaLink_pathway,query_type=annotations] [2025-06-27 21:05:30] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:30] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:31] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:05:31] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:31] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 21:05:31] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/48f6d1c796292ce438ca19de4baf3e99ff368b61-1.rds`. [2025-06-27 21:05:31] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&license=academic` [2025-06-27 21:05:31] [SUCCESS] [OmnipathR] Loaded 2487 annotation records from cache. [2025-06-27 21:05:31] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:31] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:31] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell_summary` [2025-06-27 21:05:31] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/4609206529e6ae997a8de976fe1277b3b74cc032-1.rds`. [2025-06-27 21:05:31] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/intercell_summary` [2025-06-27 21:05:31] [SUCCESS] [OmnipathR] Loaded 1098 records from cache. [2025-06-27 21:05:31] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:31] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:31] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell?scope=generic&aspect=locational&license=academic` [2025-06-27 21:05:31] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/intercell?scope=generic&aspect=locational&license=academic` [2025-06-27 21:05:31] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/intercell?scope=generic&aspect=locational&license=academic` [2025-06-27 21:05:31] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/intercell?scope=generic&aspect=locational&license=academic` [2025-06-27 21:05:31] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/intercell?scope=generic&aspect=locational&license=academic` [2025-06-27 21:05:31] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/intercell?scope=generic&aspect=locational&license=academic` [2025-06-27 21:05:31] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/intercell?scope=generic&aspect=locational&license=academic` [2025-06-27 21:05:31] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:31] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:31] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:31] [TRACE] [OmnipathR] Downloaded 31.7 Kb in 0.449283s from omnipathdb.org (70.5 Kb/s); Redirect: 0s, DNS look up: 0.001954s, Connection: 0.088174s, Pretransfer: 0.267377s, First byte at: 0.447896s [2025-06-27 21:05:32] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:05:32 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:05:32 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:05:33] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/intercell?scope=generic&aspect=locational&license=academic` [2025-06-27 21:05:33] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:33] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:34] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:34] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:34] [INFO] [OmnipathR] Cache item `f3016033f2ec7b4f644fc95cf98c28c15a2e1b8a` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:34] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/f3016033f2ec7b4f644fc95cf98c28c15a2e1b8a-1.rds`. [2025-06-27 21:05:35] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/f3016033f2ec7b4f644fc95cf98c28c15a2e1b8a-1.rds`. [2025-06-27 21:05:35] [INFO] [OmnipathR] Download ready [key=f3016033f2ec7b4f644fc95cf98c28c15a2e1b8a, version=1] [2025-06-27 21:05:35] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:35] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:35] [INFO] [OmnipathR] Cache item `f3016033f2ec7b4f644fc95cf98c28c15a2e1b8a` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:35] [SUCCESS] [OmnipathR] Downloaded 236086 intercellular communication role records. [2025-06-27 21:05:36] [TRACE] [OmnipathR] Bypassing call: `intercell_network(high_confidence = TRUE)`. [2025-06-27 21:05:36] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. [2025-06-27 21:05:36] [TRACE] [OmnipathR] Bypassing call: `filter_intercell_network(., min_curation_effort = 1, consensus_percentile = 33)`. [2025-06-27 21:05:36] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. --- finished re-building 'omnipath_intro.Rmd' --- re-building 'paths.Rmd' using rmarkdown [2025-06-27 21:05:40] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:40] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=FALSE,resources=TFcensus,entity_types=protein,query_type=annotations] [2025-06-27 21:05:40] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:40] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:41] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:05:41] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:41] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=TFcensus&entity_types=protein&license=academic` [2025-06-27 21:05:41] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=TFcensus&entity_types=protein&license=academic` [2025-06-27 21:05:41] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=TFcensus&entity_types=protein&license=academic` [2025-06-27 21:05:41] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=TFcensus&entity_types=protein&license=academic` [2025-06-27 21:05:41] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=TFcensus&entity_types=protein&license=academic` [2025-06-27 21:05:41] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=TFcensus&entity_types=protein&license=academic` [2025-06-27 21:05:41] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=TFcensus&entity_types=protein&license=academic` [2025-06-27 21:05:41] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:41] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:41] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:41] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.438122s from omnipathdb.org (35.8 Kb/s); Redirect: 0s, DNS look up: 0.001973s, Connection: 0.099938s, Pretransfer: 0.276405s, First byte at: 0.437705s [2025-06-27 21:05:41] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:05:42 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:05:42 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:05:42] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=TFcensus&entity_types=protein&license=academic` [2025-06-27 21:05:42] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:42] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:42] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:42] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:42] [INFO] [OmnipathR] Cache item `20f47c37df19181b9818be11b36773e366a53732` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:42] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/20f47c37df19181b9818be11b36773e366a53732-1.rds`. [2025-06-27 21:05:42] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/20f47c37df19181b9818be11b36773e366a53732-1.rds`. [2025-06-27 21:05:42] [INFO] [OmnipathR] Download ready [key=20f47c37df19181b9818be11b36773e366a53732, version=1] [2025-06-27 21:05:42] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:42] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:42] [INFO] [OmnipathR] Cache item `20f47c37df19181b9818be11b36773e366a53732` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:42] [SUCCESS] [OmnipathR] Downloaded 3099 annotation records. [2025-06-27 21:05:43] [TRACE] [OmnipathR] Downloading by `generic_downloader`. [2025-06-27 21:05:43] [TRACE] [OmnipathR] Looking up in cache: `https://static-content.springer.com/esm/art%3A10.1038%2Fnrg2538/MediaObjects/41576_2009_BFnrg2538_MOESM6_ESM.txt`. [2025-06-27 21:05:43] [INFO] [OmnipathR] Cache record does not exist: `https://static-content.springer.com/esm/art%3A10.1038%2Fnrg2538/MediaObjects/41576_2009_BFnrg2538_MOESM6_ESM.txt` [2025-06-27 21:05:43] [TRACE] [OmnipathR] Could not find in cache, initiating download: `https://static-content.springer.com/esm/art%3A10.1038%2Fnrg2538/MediaObjects/41576_2009_BFnrg2538_MOESM6_ESM.txt`. [2025-06-27 21:05:43] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:43] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:43] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:43] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:43] [INFO] [OmnipathR] Cache item `c36e2a3cf4ebcaf5e345791be4cbd2eeb374ddf8` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:43] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/c36e2a3cf4ebcaf5e345791be4cbd2eeb374ddf8-1.rds`. [2025-06-27 21:05:43] [INFO] [OmnipathR] Retrieving URL: `https://static-content.springer.com/esm/art%3A10.1038%2Fnrg2538/MediaObjects/41576_2009_BFnrg2538_MOESM6_ESM.txt` [2025-06-27 21:05:43] [TRACE] [OmnipathR] Attempt 1/3: `https://static-content.springer.com/esm/art%3A10.1038%2Fnrg2538/MediaObjects/41576_2009_BFnrg2538_MOESM6_ESM.txt` [2025-06-27 21:05:43] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:43] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:43] [TRACE] [OmnipathR] HTTP v2 GET: status 200. [2025-06-27 21:05:43] [TRACE] [OmnipathR] Downloaded 10.8 Kb in 0.075373s from static-content.springer.com (142.7 Kb/s); Redirect: 0s, DNS look up: 0.026911s, Connection: 0.037996s, Pretransfer: 0.061447s, First byte at: 0.073906s [2025-06-27 21:05:43] [TRACE] [OmnipathR] HTTP headers: HTTP/2 200 ; content-type: application/octet-stream; x-guploader-uploadid: AAO2Vwo-nASkrlSMWjrubMKjSiLZ3wX-1hCkOewJOA0QHbzfyALW1kfYyomJZlF0QDNqdQ1E; cache-control: private, max-age=86400; last-modified: Thu, 16 Nov 2023 16:51:13 GMT; etag: "daa03c1eafd00cad9456b660ca85b849"; x-goog-generation: 1700153472991609; x-goog-metageneration: 1; x-goog-stored-content-encoding: identity; x-goog-stored-content-length: 160972; x-goog-hash: crc32c=v/3p0Q==; x-goog-hash: md5=2qA8Hq/QDK2UVrZgyoW4SQ==; x-goog-storage-class: MULTI_REGIONAL; server: UploadServer; x-cdn-origin: GCS, SNPaaS; accept-ranges: bytes; age: 86204; date: Sat, 28 Jun 2025 01:05:43 GMT; via: 1.1 varnish; x-served-by: cache-nyc-kteb1890095-NYC; x-cache: HIT; x-cache-hits: 0; x-timer: S1751072744.926614,VS0,VE2; vary: Origin; alt-svc: h3=":443";ma=86400,h3-29=":443";ma=86400,h3-27=":443";ma=86400; content-length: 160972 [2025-06-27 21:05:43] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/c36e2a3cf4ebcaf5e345791be4cbd2eeb374ddf8-1.rds`. [2025-06-27 21:05:43] [INFO] [OmnipathR] Download ready [key=c36e2a3cf4ebcaf5e345791be4cbd2eeb374ddf8, version=1] [2025-06-27 21:05:43] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:44] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:44] [INFO] [OmnipathR] Cache item `c36e2a3cf4ebcaf5e345791be4cbd2eeb374ddf8` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:44] [SUCCESS] [OmnipathR] TF census (static-content.springer.com): downloaded 1987 records [2025-06-27 21:05:44] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:44] [TRACE] [OmnipathR] Arguments for OmniPath query: [dorothea_levels=[A,B,C],entity_types=protein,query_type=interactions] [2025-06-27 21:05:44] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:44] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:44] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B,C&fields=sources,references,curation_effort,dorothea_level&entity_types=protein&license=academic` [2025-06-27 21:05:44] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B,C&fields=sources,references,curation_effort,dorothea_level&entity_types=protein&license=academic` [2025-06-27 21:05:44] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B,C&fields=sources,references,curation_effort,dorothea_level&entity_types=protein&license=academic` [2025-06-27 21:05:44] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B,C&fields=sources,references,curation_effort,dorothea_level&entity_types=protein&license=academic` [2025-06-27 21:05:44] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B,C&fields=sources,references,curation_effort,dorothea_level&entity_types=protein&license=academic` [2025-06-27 21:05:44] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B,C&fields=sources,references,curation_effort,dorothea_level&entity_types=protein&license=academic` [2025-06-27 21:05:44] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B,C&fields=sources,references,curation_effort,dorothea_level&entity_types=protein&license=academic` [2025-06-27 21:05:44] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:44] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:44] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:44] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.421398s from omnipathdb.org (37.2 Kb/s); Redirect: 0s, DNS look up: 0.001998s, Connection: 0.082033s, Pretransfer: 0.261541s, First byte at: 0.420945s [2025-06-27 21:05:44] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:05:45 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:05:45 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:05:46] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea,tf_target,collectri&organisms=9606&dorothea_levels=A,B,C&fields=sources,references,curation_effort,dorothea_level&entity_types=protein&license=academic` [2025-06-27 21:05:46] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:46] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:46] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:46] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:46] [INFO] [OmnipathR] Cache item `6a345040ad2eaef2ab94e12a1b14630e991963ba` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:46] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/6a345040ad2eaef2ab94e12a1b14630e991963ba-1.rds`. [2025-06-27 21:05:46] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/6a345040ad2eaef2ab94e12a1b14630e991963ba-1.rds`. [2025-06-27 21:05:46] [INFO] [OmnipathR] Download ready [key=6a345040ad2eaef2ab94e12a1b14630e991963ba, version=1] [2025-06-27 21:05:46] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:46] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:46] [INFO] [OmnipathR] Cache item `6a345040ad2eaef2ab94e12a1b14630e991963ba` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:53] [SUCCESS] [OmnipathR] Downloaded 121170 interactions. [2025-06-27 21:05:53] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:05:53] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=[Ramilowski_location,UniProt_location,HPA_subcellular],entity_types=protein,query_type=annotations] [2025-06-27 21:05:53] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:53] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:53] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:05:53] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:54] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=Ramilowski_location,UniProt_location,HPA_subcellular&entity_types=protein&license=academic` [2025-06-27 21:05:54] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=Ramilowski_location,UniProt_location,HPA_subcellular&entity_types=protein&license=academic` [2025-06-27 21:05:54] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=Ramilowski_location,UniProt_location,HPA_subcellular&entity_types=protein&license=academic` [2025-06-27 21:05:54] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=Ramilowski_location,UniProt_location,HPA_subcellular&entity_types=protein&license=academic` [2025-06-27 21:05:54] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=Ramilowski_location,UniProt_location,HPA_subcellular&entity_types=protein&license=academic` [2025-06-27 21:05:54] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=Ramilowski_location,UniProt_location,HPA_subcellular&entity_types=protein&license=academic` [2025-06-27 21:05:54] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=Ramilowski_location,UniProt_location,HPA_subcellular&entity_types=protein&license=academic` [2025-06-27 21:05:54] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:54] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:54] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:54] [TRACE] [OmnipathR] Downloaded 31.7 Kb in 0.430783s from omnipathdb.org (73.5 Kb/s); Redirect: 0s, DNS look up: 0.002107s, Connection: 0.083725s, Pretransfer: 0.257267s, First byte at: 0.429463s [2025-06-27 21:05:54] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:05:55 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:05:55 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:05:56] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=Ramilowski_location,UniProt_location,HPA_subcellular&entity_types=protein&license=academic` [2025-06-27 21:05:56] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:56] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:56] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:56] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:56] [INFO] [OmnipathR] Cache item `d22e19552744752ac693b8572b5e500433b4f65b` version 1: status changed from `unknown` to `started`. [2025-06-27 21:05:56] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/d22e19552744752ac693b8572b5e500433b4f65b-1.rds`. [2025-06-27 21:05:57] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/d22e19552744752ac693b8572b5e500433b4f65b-1.rds`. [2025-06-27 21:05:57] [INFO] [OmnipathR] Download ready [key=d22e19552744752ac693b8572b5e500433b4f65b, version=1] [2025-06-27 21:05:57] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:05:57] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:05:57] [INFO] [OmnipathR] Cache item `d22e19552744752ac693b8572b5e500433b4f65b` version 1: status changed from `started` to `ready`. [2025-06-27 21:05:57] [SUCCESS] [OmnipathR] Downloaded 353573 annotation records. [2025-06-27 21:05:59] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:05:59] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:05:59] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell?entity_types=protein&parent=ligand&topology=secreted&license=academic` [2025-06-27 21:05:59] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/intercell?entity_types=protein&parent=ligand&topology=secreted&license=academic` [2025-06-27 21:05:59] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/intercell?entity_types=protein&parent=ligand&topology=secreted&license=academic` [2025-06-27 21:05:59] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/intercell?entity_types=protein&parent=ligand&topology=secreted&license=academic` [2025-06-27 21:05:59] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/intercell?entity_types=protein&parent=ligand&topology=secreted&license=academic` [2025-06-27 21:05:59] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/intercell?entity_types=protein&parent=ligand&topology=secreted&license=academic` [2025-06-27 21:05:59] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/intercell?entity_types=protein&parent=ligand&topology=secreted&license=academic` [2025-06-27 21:05:59] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:05:59] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:05:59] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:05:59] [TRACE] [OmnipathR] Downloaded 31.7 Kb in 0.437115s from omnipathdb.org (72.4 Kb/s); Redirect: 0s, DNS look up: 0.001968s, Connection: 0.092552s, Pretransfer: 0.265113s, First byte at: 0.435595s [2025-06-27 21:05:59] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:06:00 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:06:00 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:06:00] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/intercell?entity_types=protein&parent=ligand&topology=secreted&license=academic` [2025-06-27 21:06:00] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:00] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:00] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:00] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:00] [INFO] [OmnipathR] Cache item `8b4df10feeee656d8460263705d94f8a1d129497` version 1: status changed from `unknown` to `started`. [2025-06-27 21:06:00] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/8b4df10feeee656d8460263705d94f8a1d129497-1.rds`. [2025-06-27 21:06:00] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/8b4df10feeee656d8460263705d94f8a1d129497-1.rds`. [2025-06-27 21:06:00] [INFO] [OmnipathR] Download ready [key=8b4df10feeee656d8460263705d94f8a1d129497, version=1] [2025-06-27 21:06:00] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:00] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:00] [INFO] [OmnipathR] Cache item `8b4df10feeee656d8460263705d94f8a1d129497` version 1: status changed from `started` to `ready`. [2025-06-27 21:06:00] [SUCCESS] [OmnipathR] Downloaded 10040 intercellular communication role records. [2025-06-27 21:06:00] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:00] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:00] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:00] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:01] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:01] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:01] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:01] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:01] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:01] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:06:01] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:06:01] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:06:01] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.428773s from omnipathdb.org (36.5 Kb/s); Redirect: 0s, DNS look up: 0.002059s, Connection: 0.082286s, Pretransfer: 0.268209s, First byte at: 0.427899s [2025-06-27 21:06:01] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:06:02 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:06:02 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:06:02] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:02] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:02] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:02] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:02] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:02] [INFO] [OmnipathR] Cache item `9ecbbba7b7129c316d69501f7af5c2aced05a498` version 1: status changed from `unknown` to `started`. [2025-06-27 21:06:02] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/9ecbbba7b7129c316d69501f7af5c2aced05a498-1.rds`. [2025-06-27 21:06:02] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/9ecbbba7b7129c316d69501f7af5c2aced05a498-1.rds`. [2025-06-27 21:06:02] [INFO] [OmnipathR] Download ready [key=9ecbbba7b7129c316d69501f7af5c2aced05a498, version=1] [2025-06-27 21:06:02] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:02] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:02] [INFO] [OmnipathR] Cache item `9ecbbba7b7129c316d69501f7af5c2aced05a498` version 1: status changed from `started` to `ready`. [2025-06-27 21:06:02] [SUCCESS] [OmnipathR] Downloaded 21862 intercellular communication role records. [2025-06-27 21:06:02] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:02] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:02] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell?entity_types=protein&parent=receptor&topology=plasma_membrane_transmembrane&license=academic` [2025-06-27 21:06:02] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/intercell?entity_types=protein&parent=receptor&topology=plasma_membrane_transmembrane&license=academic` [2025-06-27 21:06:02] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/intercell?entity_types=protein&parent=receptor&topology=plasma_membrane_transmembrane&license=academic` [2025-06-27 21:06:02] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/intercell?entity_types=protein&parent=receptor&topology=plasma_membrane_transmembrane&license=academic` [2025-06-27 21:06:02] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/intercell?entity_types=protein&parent=receptor&topology=plasma_membrane_transmembrane&license=academic` [2025-06-27 21:06:02] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/intercell?entity_types=protein&parent=receptor&topology=plasma_membrane_transmembrane&license=academic` [2025-06-27 21:06:02] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/intercell?entity_types=protein&parent=receptor&topology=plasma_membrane_transmembrane&license=academic` [2025-06-27 21:06:02] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:06:02] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:06:03] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:06:03] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.408149s from omnipathdb.org (38.4 Kb/s); Redirect: 0s, DNS look up: 0.002144s, Connection: 0.081724s, Pretransfer: 0.24867s, First byte at: 0.407414s [2025-06-27 21:06:03] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:06:03 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:06:03 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:06:04] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/intercell?entity_types=protein&parent=receptor&topology=plasma_membrane_transmembrane&license=academic` [2025-06-27 21:06:04] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:04] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:04] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:04] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:04] [INFO] [OmnipathR] Cache item `958b54b673bc1257aa3dafe979574736ad7d4632` version 1: status changed from `unknown` to `started`. [2025-06-27 21:06:04] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/958b54b673bc1257aa3dafe979574736ad7d4632-1.rds`. [2025-06-27 21:06:04] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/958b54b673bc1257aa3dafe979574736ad7d4632-1.rds`. [2025-06-27 21:06:04] [INFO] [OmnipathR] Download ready [key=958b54b673bc1257aa3dafe979574736ad7d4632, version=1] [2025-06-27 21:06:04] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:04] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:04] [INFO] [OmnipathR] Cache item `958b54b673bc1257aa3dafe979574736ad7d4632` version 1: status changed from `started` to `ready`. [2025-06-27 21:06:04] [SUCCESS] [OmnipathR] Downloaded 21455 intercellular communication role records. [2025-06-27 21:06:04] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:04] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:04] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:04] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/9ecbbba7b7129c316d69501f7af5c2aced05a498-1.rds`. [2025-06-27 21:06:04] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:04] [SUCCESS] [OmnipathR] Loaded 21862 intercellular communication role records from cache. [2025-06-27 21:06:05] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:05] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:05] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell?entity_types=protein&topology=secreted&causality=trans&license=academic` [2025-06-27 21:06:05] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/intercell?entity_types=protein&topology=secreted&causality=trans&license=academic` [2025-06-27 21:06:05] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/intercell?entity_types=protein&topology=secreted&causality=trans&license=academic` [2025-06-27 21:06:05] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/intercell?entity_types=protein&topology=secreted&causality=trans&license=academic` [2025-06-27 21:06:05] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/intercell?entity_types=protein&topology=secreted&causality=trans&license=academic` [2025-06-27 21:06:05] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/intercell?entity_types=protein&topology=secreted&causality=trans&license=academic` [2025-06-27 21:06:05] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/intercell?entity_types=protein&topology=secreted&causality=trans&license=academic` [2025-06-27 21:06:05] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:06:05] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:06:05] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:06:05] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.430211s from omnipathdb.org (36.4 Kb/s); Redirect: 0s, DNS look up: 0.002214s, Connection: 0.094467s, Pretransfer: 0.263644s, First byte at: 0.429363s [2025-06-27 21:06:05] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:06:06 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:06:06 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:06:06] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/intercell?entity_types=protein&topology=secreted&causality=trans&license=academic` [2025-06-27 21:06:06] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:06] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:06] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:06] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:06] [INFO] [OmnipathR] Cache item `f7af75e239c9ffc6d21bad01972722f2f0180e87` version 1: status changed from `unknown` to `started`. [2025-06-27 21:06:06] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/f7af75e239c9ffc6d21bad01972722f2f0180e87-1.rds`. [2025-06-27 21:06:06] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/f7af75e239c9ffc6d21bad01972722f2f0180e87-1.rds`. [2025-06-27 21:06:06] [INFO] [OmnipathR] Download ready [key=f7af75e239c9ffc6d21bad01972722f2f0180e87, version=1] [2025-06-27 21:06:06] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:06] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:06] [INFO] [OmnipathR] Cache item `f7af75e239c9ffc6d21bad01972722f2f0180e87` version 1: status changed from `started` to `ready`. [2025-06-27 21:06:06] [SUCCESS] [OmnipathR] Downloaded 14602 intercellular communication role records. [2025-06-27 21:06:06] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:06] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:06] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:07] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/9ecbbba7b7129c316d69501f7af5c2aced05a498-1.rds`. [2025-06-27 21:06:07] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:07] [SUCCESS] [OmnipathR] Loaded 21862 intercellular communication role records from cache. [2025-06-27 21:06:07] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:07] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:07] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell?entity_types=protein&topology=plasma_membrane_transmembrane&causality=rec&license=academic` [2025-06-27 21:06:07] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/intercell?entity_types=protein&topology=plasma_membrane_transmembrane&causality=rec&license=academic` [2025-06-27 21:06:07] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/intercell?entity_types=protein&topology=plasma_membrane_transmembrane&causality=rec&license=academic` [2025-06-27 21:06:07] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/intercell?entity_types=protein&topology=plasma_membrane_transmembrane&causality=rec&license=academic` [2025-06-27 21:06:07] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/intercell?entity_types=protein&topology=plasma_membrane_transmembrane&causality=rec&license=academic` [2025-06-27 21:06:07] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/intercell?entity_types=protein&topology=plasma_membrane_transmembrane&causality=rec&license=academic` [2025-06-27 21:06:07] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/intercell?entity_types=protein&topology=plasma_membrane_transmembrane&causality=rec&license=academic` [2025-06-27 21:06:07] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:06:07] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:06:07] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:06:07] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.416169s from omnipathdb.org (37.6 Kb/s); Redirect: 0s, DNS look up: 0.001913s, Connection: 0.083589s, Pretransfer: 0.253619s, First byte at: 0.415269s [2025-06-27 21:06:07] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:06:08 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:06:08 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:06:08] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/intercell?entity_types=protein&topology=plasma_membrane_transmembrane&causality=rec&license=academic` [2025-06-27 21:06:08] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:08] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:08] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:08] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:08] [INFO] [OmnipathR] Cache item `72c58fa11451e57015edbfc8235d55d71f9d7362` version 1: status changed from `unknown` to `started`. [2025-06-27 21:06:09] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/72c58fa11451e57015edbfc8235d55d71f9d7362-1.rds`. [2025-06-27 21:06:09] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/72c58fa11451e57015edbfc8235d55d71f9d7362-1.rds`. [2025-06-27 21:06:09] [INFO] [OmnipathR] Download ready [key=72c58fa11451e57015edbfc8235d55d71f9d7362, version=1] [2025-06-27 21:06:09] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:09] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:09] [INFO] [OmnipathR] Cache item `72c58fa11451e57015edbfc8235d55d71f9d7362` version 1: status changed from `started` to `ready`. [2025-06-27 21:06:09] [SUCCESS] [OmnipathR] Downloaded 26412 intercellular communication role records. [2025-06-27 21:06:09] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:09] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:09] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:09] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/9ecbbba7b7129c316d69501f7af5c2aced05a498-1.rds`. [2025-06-27 21:06:09] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/intercell?aspect=locational&parent=secreted,plasma_membrane_transmembrane,plasma_membrane_peripheral&license=academic` [2025-06-27 21:06:09] [SUCCESS] [OmnipathR] Loaded 21862 intercellular communication role records from cache. [2025-06-27 21:06:09] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:06:09] [TRACE] [OmnipathR] Arguments for OmniPath query: [datasets=omnipath,entity_types=protein] [2025-06-27 21:06:09] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:06:09] [TRACE] [OmnipathR] Arguments for OmniPath query: [datasets=omnipath,entity_types=protein,query_type=interactions] [2025-06-27 21:06:09] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:09] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:09] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:09] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:09] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:10] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:10] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:10] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:10] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:10] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:06:10] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:06:10] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:06:10] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.432879s from omnipathdb.org (36.2 Kb/s); Redirect: 0s, DNS look up: 0.002046s, Connection: 0.08805s, Pretransfer: 0.269514s, First byte at: 0.432519s [2025-06-27 21:06:10] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:06:11 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:06:11 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:06:11] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=omnipath&organisms=9606&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:11] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:11] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:11] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:11] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:11] [INFO] [OmnipathR] Cache item `4531fff8a97521fefd85568643520d934e90659c` version 1: status changed from `unknown` to `started`. [2025-06-27 21:06:12] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/4531fff8a97521fefd85568643520d934e90659c-1.rds`. [2025-06-27 21:06:12] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/4531fff8a97521fefd85568643520d934e90659c-1.rds`. [2025-06-27 21:06:12] [INFO] [OmnipathR] Download ready [key=4531fff8a97521fefd85568643520d934e90659c, version=1] [2025-06-27 21:06:12] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:12] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:12] [INFO] [OmnipathR] Cache item `4531fff8a97521fefd85568643520d934e90659c` version 1: status changed from `started` to `ready`. [2025-06-27 21:06:13] [SUCCESS] [OmnipathR] Downloaded 30053 interactions. [2025-06-27 21:06:14] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:06:14] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=SignaLink_pathway,entity_types=protein,query_type=annotations] [2025-06-27 21:06:14] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:14] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:14] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:06:14] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:14] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&entity_types=protein&license=academic` [2025-06-27 21:06:14] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&entity_types=protein&license=academic` [2025-06-27 21:06:14] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=SignaLink_pathway&entity_types=protein&license=academic` [2025-06-27 21:06:14] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=SignaLink_pathway&entity_types=protein&license=academic` [2025-06-27 21:06:14] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=SignaLink_pathway&entity_types=protein&license=academic` [2025-06-27 21:06:14] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&entity_types=protein&license=academic` [2025-06-27 21:06:14] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&entity_types=protein&license=academic` [2025-06-27 21:06:14] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:06:14] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:06:15] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:06:15] [TRACE] [OmnipathR] Downloaded 13.1 Kb in 0.440763s from omnipathdb.org (29.7 Kb/s); Redirect: 0s, DNS look up: 0.002107s, Connection: 0.082639s, Pretransfer: 0.278053s, First byte at: 0.440401s [2025-06-27 21:06:15] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:06:15 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:06:15 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:06:15] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=SignaLink_pathway&entity_types=protein&license=academic` [2025-06-27 21:06:15] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:15] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:16] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:16] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:16] [INFO] [OmnipathR] Cache item `6061f30dac10cc2b0f8bcf13f7d870c3d69a0df8` version 1: status changed from `unknown` to `started`. [2025-06-27 21:06:16] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/6061f30dac10cc2b0f8bcf13f7d870c3d69a0df8-1.rds`. [2025-06-27 21:06:16] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/6061f30dac10cc2b0f8bcf13f7d870c3d69a0df8-1.rds`. [2025-06-27 21:06:16] [INFO] [OmnipathR] Download ready [key=6061f30dac10cc2b0f8bcf13f7d870c3d69a0df8, version=1] [2025-06-27 21:06:16] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:16] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:16] [INFO] [OmnipathR] Cache item `6061f30dac10cc2b0f8bcf13f7d870c3d69a0df8` version 1: status changed from `started` to `ready`. [2025-06-27 21:06:16] [SUCCESS] [OmnipathR] Downloaded 1144 annotation records. [2025-06-27 21:06:16] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:06:16] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=SignaLink_function,entity_types=protein,query_type=annotations] [2025-06-27 21:06:16] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:16] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:17] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:06:17] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:17] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=SignaLink_function&entity_types=protein&license=academic` [2025-06-27 21:06:17] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=SignaLink_function&entity_types=protein&license=academic` [2025-06-27 21:06:17] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=SignaLink_function&entity_types=protein&license=academic` [2025-06-27 21:06:17] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=SignaLink_function&entity_types=protein&license=academic` [2025-06-27 21:06:17] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=SignaLink_function&entity_types=protein&license=academic` [2025-06-27 21:06:17] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=SignaLink_function&entity_types=protein&license=academic` [2025-06-27 21:06:17] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=SignaLink_function&entity_types=protein&license=academic` [2025-06-27 21:06:17] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:06:17] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:06:17] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:06:17] [TRACE] [OmnipathR] Downloaded 12.1 Kb in 0.418456s from omnipathdb.org (28.9 Kb/s); Redirect: 0s, DNS look up: 0.002234s, Connection: 0.086099s, Pretransfer: 0.257353s, First byte at: 0.418121s [2025-06-27 21:06:17] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:06:18 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:06:18 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:06:18] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=SignaLink_function&entity_types=protein&license=academic` [2025-06-27 21:06:18] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:18] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:18] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:18] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:18] [INFO] [OmnipathR] Cache item `ec1ffe714d7618308311e03ab5d91a72b6ab30a3` version 1: status changed from `unknown` to `started`. [2025-06-27 21:06:18] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/ec1ffe714d7618308311e03ab5d91a72b6ab30a3-1.rds`. [2025-06-27 21:06:18] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/ec1ffe714d7618308311e03ab5d91a72b6ab30a3-1.rds`. [2025-06-27 21:06:18] [INFO] [OmnipathR] Download ready [key=ec1ffe714d7618308311e03ab5d91a72b6ab30a3, version=1] [2025-06-27 21:06:18] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:18] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:18] [INFO] [OmnipathR] Cache item `ec1ffe714d7618308311e03ab5d91a72b6ab30a3` version 1: status changed from `started` to `ready`. [2025-06-27 21:06:18] [SUCCESS] [OmnipathR] Downloaded 1080 annotation records. [2025-06-27 21:06:21] [TRACE] [OmnipathR] Bypassing call: `simplify_intercell_network(.)`. [2025-06-27 21:06:21] [TRACE] [OmnipathR] This behaviour is intended for running R CMD check within limited time and is triggered solely by the user name. Please report if you see this anywhere outside of a Bioconductor build server. [2025-06-27 21:06:21] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:06:21] [TRACE] [OmnipathR] Arguments for OmniPath query: [dorothea_levels=[A,B],datasets=tf_target,entity_types=protein,resources=[ORegAnno,PAZAR],query_type=interactions] [2025-06-27 21:06:21] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:21] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:21] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:06:21] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:21] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=ORegAnno,PAZAR&datasets=tf_target&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:21] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&resources=ORegAnno,PAZAR&datasets=tf_target&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:21] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=ORegAnno,PAZAR&datasets=tf_target&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:21] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=ORegAnno,PAZAR&datasets=tf_target&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:21] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&resources=ORegAnno,PAZAR&datasets=tf_target&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:21] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&resources=ORegAnno,PAZAR&datasets=tf_target&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:21] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&resources=ORegAnno,PAZAR&datasets=tf_target&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:21] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:06:21] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:06:22] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:06:22] [TRACE] [OmnipathR] Downloaded 11.7 Kb in 0.408372s from omnipathdb.org (28.7 Kb/s); Redirect: 0s, DNS look up: 0.002073s, Connection: 0.081877s, Pretransfer: 0.249645s, First byte at: 0.408018s [2025-06-27 21:06:22] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:06:22 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:06:22 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:06:23] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&resources=ORegAnno,PAZAR&datasets=tf_target&organisms=9606&dorothea_levels=A,B&fields=sources,references,curation_effort&entity_types=protein&license=academic` [2025-06-27 21:06:23] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:23] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:23] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:23] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:23] [INFO] [OmnipathR] Cache item `eb0c13fd817d7fa62717fa239f8a329e85dcac2e` version 1: status changed from `unknown` to `started`. [2025-06-27 21:06:23] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/eb0c13fd817d7fa62717fa239f8a329e85dcac2e-1.rds`. [2025-06-27 21:06:23] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/eb0c13fd817d7fa62717fa239f8a329e85dcac2e-1.rds`. [2025-06-27 21:06:23] [INFO] [OmnipathR] Download ready [key=eb0c13fd817d7fa62717fa239f8a329e85dcac2e, version=1] [2025-06-27 21:06:23] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:23] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:23] [INFO] [OmnipathR] Cache item `eb0c13fd817d7fa62717fa239f8a329e85dcac2e` version 1: status changed from `started` to `ready`. [2025-06-27 21:06:23] [SUCCESS] [OmnipathR] Downloaded 322 interactions. [2025-06-27 21:06:23] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:06:23] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=FALSE,resources=UniProt_location,query_type=annotations] [2025-06-27 21:06:23] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:23] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:24] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:06:24] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:24] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 21:06:24] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/f2e7cc5e753cd4e22d458171359dea86781ebae8-1.rds`. [2025-06-27 21:06:24] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 21:06:24] [SUCCESS] [OmnipathR] Loaded 76260 annotation records from cache. [2025-06-27 21:06:24] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:06:24] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=FALSE,resources=kinase.com,query_type=annotations] [2025-06-27 21:06:24] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:24] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:25] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:06:25] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:25] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=kinase.com&license=academic` [2025-06-27 21:06:25] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=kinase.com&license=academic` [2025-06-27 21:06:25] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=kinase.com&license=academic` [2025-06-27 21:06:25] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=kinase.com&license=academic` [2025-06-27 21:06:25] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=kinase.com&license=academic` [2025-06-27 21:06:25] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=kinase.com&license=academic` [2025-06-27 21:06:25] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=kinase.com&license=academic` [2025-06-27 21:06:25] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`. [2025-06-27 21:06:25] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2] [2025-06-27 21:06:25] [TRACE] [OmnipathR] HTTP v1 GET: status 200. [2025-06-27 21:06:25] [TRACE] [OmnipathR] Downloaded 20.2 Kb in 0.434483s from omnipathdb.org (46.4 Kb/s); Redirect: 0s, DNS look up: 0.002068s, Connection: 0.090063s, Pretransfer: 0.261169s, First byte at: 0.433889s [2025-06-27 21:06:25] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Sat, 28 Jun 2025 01:06:26 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Sat, 28 Jun 2025 02:06:26 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip [2025-06-27 21:06:26] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=kinase.com&license=academic` [2025-06-27 21:06:26] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:26] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:26] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:26] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:26] [INFO] [OmnipathR] Cache item `422914ef8903d8480f1b9fbb47096e275567851d` version 1: status changed from `unknown` to `started`. [2025-06-27 21:06:26] [TRACE] [OmnipathR] Exporting object to RDS: `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/422914ef8903d8480f1b9fbb47096e275567851d-1.rds`. [2025-06-27 21:06:26] [TRACE] [OmnipathR] Exported RDS to `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/422914ef8903d8480f1b9fbb47096e275567851d-1.rds`. [2025-06-27 21:06:27] [INFO] [OmnipathR] Download ready [key=422914ef8903d8480f1b9fbb47096e275567851d, version=1] [2025-06-27 21:06:27] [TRACE] [OmnipathR] Reading JSON from `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/cache.json` (encoding: UTF-8). [2025-06-27 21:06:27] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:27] [INFO] [OmnipathR] Cache item `422914ef8903d8480f1b9fbb47096e275567851d` version 1: status changed from `started` to `ready`. [2025-06-27 21:06:27] [SUCCESS] [OmnipathR] Downloaded 2029 annotation records. [2025-06-27 21:06:30] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:06:30] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=FALSE,resources=UniProt_location,query_type=annotations] [2025-06-27 21:06:30] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:30] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:31] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:06:31] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:31] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 21:06:31] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/f2e7cc5e753cd4e22d458171359dea86781ebae8-1.rds`. [2025-06-27 21:06:31] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/annotations?resources=UniProt_location&license=academic` [2025-06-27 21:06:31] [SUCCESS] [OmnipathR] Loaded 76260 annotation records from cache. [2025-06-27 21:06:31] [TRACE] [OmnipathR] Processing args for OmniPath query [2025-06-27 21:06:31] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=FALSE,resources=kinase.com,query_type=annotations] [2025-06-27 21:06:31] [TRACE] [OmnipathR] Organism(s): 9606 [2025-06-27 21:06:31] [TRACE] [OmnipathR] Orthology targets: [2025-06-27 21:06:32] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8). [2025-06-27 21:06:32] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-06-27 21:06:32] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=kinase.com&license=academic` [2025-06-27 21:06:32] [TRACE] [OmnipathR] Loaded data from RDS `C:\Users\biocbuild\AppData\Local\Cache\OmnipathR/422914ef8903d8480f1b9fbb47096e275567851d-1.rds`. [2025-06-27 21:06:32] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/annotations?resources=kinase.com&license=academic` [2025-06-27 21:06:32] [SUCCESS] [OmnipathR] Loaded 2029 annotation records from cache. --- finished re-building 'paths.Rmd' SUMMARY: processing the following file failed: 'cosmos.Rmd' Error: Vignette re-building failed. Execution halted