############################################################################## ############################################################################## ### ### Running command: ### ### /Library/Frameworks/R.framework/Resources/bin/R CMD check --install=check:OmnipathR.install-out.txt --library=/Library/Frameworks/R.framework/Resources/library --no-vignettes --timings OmnipathR_3.18.0.tar.gz ### ############################################################################## ############################################################################## * using log directory ‘/Users/biocbuild/bbs-3.22-bioc/meat/OmnipathR.Rcheck’ * using R version 4.5.1 Patched (2025-09-10 r88807) * using platform: aarch64-apple-darwin20 * R was compiled by Apple clang version 16.0.0 (clang-1600.0.26.6) GNU Fortran (GCC) 14.2.0 * running under: macOS Ventura 13.7.7 * using session charset: UTF-8 * using option ‘--no-vignettes’ * checking for file ‘OmnipathR/DESCRIPTION’ ... OK * checking extension type ... Package * this is package ‘OmnipathR’ version ‘3.18.0’ * package encoding: UTF-8 * checking package namespace information ... OK * checking package dependencies ... INFO Imports includes 35 non-default packages. Importing from so many packages makes the package vulnerable to any of them becoming unavailable. Move as many as possible to Suggests and use conditionally. * checking if this is a source package ... OK * checking if there is a namespace ... OK * checking for hidden files and directories ... OK * checking for portable file names ... OK * checking for sufficient/correct file permissions ... OK * checking whether package ‘OmnipathR’ can be installed ... OK * checking installed package size ... OK * checking package directory ... OK * checking DESCRIPTION meta-information ... OK * checking top-level files ... OK * checking for left-over files ... OK * checking index information ... OK * checking package subdirectories ... OK * checking code files for non-ASCII characters ... OK * checking R files for syntax errors ... OK * checking whether the package can be loaded ... OK * checking whether the package can be loaded with stated dependencies ... OK * checking whether the package can be unloaded cleanly ... OK * checking whether the namespace can be loaded with stated dependencies ... OK * checking whether the namespace can be unloaded cleanly ... OK * checking whether startup messages can be suppressed ... NOTE [2025-11-10 21:26:44] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8). [2025-11-10 21:26:44] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:44] [INFO] [OmnipathR] Initialized cache: `/Users/biocbuild/Library/Caches/OmnipathR`. [2025-11-10 21:26:44] [INFO] [OmnipathR] Package `OmnipathR` packaged: NA [2025-11-10 21:26:44] [INFO] [OmnipathR] Package `OmnipathR` date/publication: 2025-11-10 [2025-11-10 21:26:44] [INFO] [OmnipathR] Package `OmnipathR` built: R 4.5.1; ; 2025-11-10 20:05:02 UTC; unix [2025-11-10 21:26:44] [INFO] [OmnipathR] Package `OmnipathR` version: 3.18.0 [2025-11-10 21:26:44] [INFO] [OmnipathR] Package `OmnipathR` repository: Bioconductor 3.22 [2025-11-10 21:26:45] [INFO] [OmnipathR] Session info: [version=R version 4.5.1 Patched (2025-09-10 r88807); os=macOS Ventura 13.7.7; system=aarch64, darwin20; ui=X11; language=(EN); collate=C; ctype=en_US.UTF-8; tz=America/New_York; date=2025-11-10; pandoc=3.1.12.3 @ /opt/homebrew/bin/ (via rmarkdown); quarto=1.7.32 @ /usr/local/bin/quarto] [2025-11-10 21:26:45] [INFO] [OmnipathR] External libraries: [cairo=1.17.6; cairoFT=; pango=1.50.14; png=1.6.44; jpeg=9.5; tiff=LIBTIFF, Version 4.5.0; tcl=8.6.13; curl=8.7.1; zlib=1.2.11; bzlib=1.0.8, 13-Jul-2019; xz=5.6.3; deflate=1.23; PCRE=10.44 2024-06-07; ICU=70.2; TRE=TRE 0.8.0 R_fixes (BSD); iconv=Apple or GNU libiconv 1.11 /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libR.dylib; readline=5.2; BLAS=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRblas.0.dylib; lapack=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRlapack.dylib; lapack_version=3.12.1] [2025-11-10 21:26:45] [INFO] [OmnipathR] Loaded packages: backports 1.5.0(2024-05-23); bit 4.6.0(2025-03-06); bit64 4.6.0-1(2025-01-16); blob 1.2.4(2023-03-17); cachem 1.1.0(2024-05-16); cellranger 1.1.0(2016-07-27); checkmate 2.3.3(2025-08-18); chromote 0.5.1(2025-04-24); cli 3.6.5(2025-04-23); crayon 1.5.3(2024-06-20); curl 7.0.0(2025-08-19); DBI 1.2.3(2024-06-02); digest 0.6.37(2024-08-19); dplyr 1.1.4(2023-11-17); evaluate 1.0.5(2025-08-27); fastmap 1.2.0(2024-05-15); fs 1.6.6(2025-04-12); generics 0.1.4(2025-05-09); glue 1.8.0(2024-09-30); hms 1.1.4(2025-10-17); htmltools 0.5.8.1(2024-04-04); httr 1.4.7(2023-08-15); httr2 1.2.1(2025-07-22); igraph 2.2.1(2025-10-27); jsonlite 2.0.0(2025-03-27); knitr 1.50(2025-03-16); later 1.4.4(2025-08-27); lifecycle 1.0.4(2023-11-07); logger 0.4.1(2025-09-11); lubridate 1.9.4(2024-12-08); magrittr 2.0.4(2025-09-12); memoise 2.0.1(2021-11-26); OmnipathR 3.18.0(2025-11-10); otel 0.2.0(2025-08-29); pillar 1.11.1(2025-09-17); pkgconfig 2.0.3(2019-09-22); prettyunits 1.2.0(2023-09-24); processx 3.8.6(2025-02-21); progress 1.2.3(2023-12-06); promises 1.5.0(2025-11-01); ps 1.9.1(2025-04-12); purrr 1.2.0(2025-11-04); R.methodsS3 1.8.2(2022-06-13); R.oo 1.27.1(2025-05-02); R.utils 2.13.0(2025-02-24); R6 2.6.1(2025-02-15); rappdirs 0.3.3(2021-01-31); Rcpp 1.1.0(2025-07-02); readr 2.1.5(2024-01-10); readxl 1.4.5(2025-03-07); rlang 1.1.6(2025-04-11); rmarkdown 2.30(2025-09-28); RSQLite 2.4.4(2025-11-10); rvest 1.0.5(2025-08-29); sessioninfo 1.2.3(2025-02-05); stringi 1.8.7(2025-03-27); stringr 1.6.0(2025-11-04); tibble 3.3.0(2025-06-08); tidyr 1.3.1(2024-01-24); tidyselect 1.2.1(2024-03-11); timechange 0.3.0(2024-01-18); tzdb 0.5.0(2025-03-15); vctrs 0.6.5(2023-12-01); websocket 1.4.4(2025-04-10); withr 3.0.2(2024-10-28); xfun 0.54(2025-10-30); XML 3.99-0.20(2025-11-08); xml2 1.4.1(2025-10-27); yaml 2.3.10(2024-07-26); zip 2.3.3(2025-05-13) [2025-11-10 21:26:45] [INFO] [OmnipathR] CURL: version: 8.14.1; headers: 8.14.1; ssl_version: LibreSSL/3.3.6 (SecureTransport); libz_version: 1.2.11; libssh_version: NA; libidn_version: NA; host: aarch64-apple-darwin23.6.0; protocols: dict, file, ftp, ftps, gopher, gophers, http, https, imap, imaps, ldap, ldaps, mqtt, pop3, pop3s, rtsp, smb, smbs, smtp, smtps, telnet, tftp, ws, wss; ipv6: TRUE; http2: TRUE; idn: FALSE; url_parser: TRUE [2025-11-10 21:26:45] [TRACE] [OmnipathR] Running on a build server, wiping cache. [2025-11-10 21:26:45] [TRACE] [OmnipathR] Cache is at `/Users/biocbuild/Library/Caches/OmnipathR`. [2025-11-10 21:26:45] [TRACE] [OmnipathR] Contains 1 files. [2025-11-10 21:26:45] [TRACE] [OmnipathR] Cache is locked: FALSE. [2025-11-10 21:26:45] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8). [2025-11-10 21:26:45] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:45] [SUCCESS] [OmnipathR] Removing all cache contents from `/Users/biocbuild/Library/Caches/OmnipathR`. [2025-11-10 21:26:45] [TRACE] [OmnipathR] Pandoc version: `3.1.12.3`. [2025-11-10 21:26:45] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/db/db_def.json` (encoding: UTF-8). [2025-11-10 21:26:45] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:45] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/magic_bytes.json` (encoding: UTF-8). [2025-11-10 21:26:45] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:45] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/urls.json` (encoding: UTF-8). [2025-11-10 21:26:45] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:45] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/id_types.json` (encoding: UTF-8). [2025-11-10 21:26:45] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:45] [TRACE] [OmnipathR] Cache locked: FALSE It looks like this package (or a package it requires) has a startup message which cannot be suppressed: see ?packageStartupMessage. * checking dependencies in R code ... OK * checking S3 generic/method consistency ... OK * checking replacement functions ... OK * checking foreign function calls ... OK * checking R code for possible problems ... NOTE [2025-11-10 21:26:52] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8). [2025-11-10 21:26:52] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:52] [INFO] [OmnipathR] Initialized cache: `/Users/biocbuild/Library/Caches/OmnipathR`. [2025-11-10 21:26:52] [INFO] [OmnipathR] Package `OmnipathR` packaged: NA [2025-11-10 21:26:52] [INFO] [OmnipathR] Package `OmnipathR` date/publication: 2025-11-10 [2025-11-10 21:26:52] [INFO] [OmnipathR] Package `OmnipathR` built: R 4.5.1; ; 2025-11-10 20:05:02 UTC; unix [2025-11-10 21:26:52] [INFO] [OmnipathR] Package `OmnipathR` version: 3.18.0 [2025-11-10 21:26:52] [INFO] [OmnipathR] Package `OmnipathR` repository: Bioconductor 3.22 [2025-11-10 21:26:52] [INFO] [OmnipathR] Session info: [version=R version 4.5.1 Patched (2025-09-10 r88807); os=macOS Ventura 13.7.7; system=aarch64, darwin20; ui=X11; language=(EN); collate=C; ctype=en_US.UTF-8; tz=America/New_York; date=2025-11-10; pandoc=3.1.12.3 @ /opt/homebrew/bin/ (via rmarkdown); quarto=1.7.32 @ /usr/local/bin/quarto] [2025-11-10 21:26:52] [INFO] [OmnipathR] External libraries: [cairo=1.17.6; cairoFT=; pango=1.50.14; png=1.6.44; jpeg=9.5; tiff=LIBTIFF, Version 4.5.0; tcl=8.6.13; curl=8.7.1; zlib=1.2.11; bzlib=1.0.8, 13-Jul-2019; xz=5.6.3; deflate=1.23; PCRE=10.44 2024-06-07; ICU=70.2; TRE=TRE 0.8.0 R_fixes (BSD); iconv=Apple or GNU libiconv 1.11 /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libR.dylib; readline=5.2; BLAS=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRblas.0.dylib; lapack=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRlapack.dylib; lapack_version=3.12.1] [2025-11-10 21:26:52] [INFO] [OmnipathR] Loaded packages: backports 1.5.0(2024-05-23); bit 4.6.0(2025-03-06); bit64 4.6.0-1(2025-01-16); blob 1.2.4(2023-03-17); cachem 1.1.0(2024-05-16); cellranger 1.1.0(2016-07-27); checkmate 2.3.3(2025-08-18); chromote 0.5.1(2025-04-24); cli 3.6.5(2025-04-23); crayon 1.5.3(2024-06-20); curl 7.0.0(2025-08-19); DBI 1.2.3(2024-06-02); digest 0.6.37(2024-08-19); dplyr 1.1.4(2023-11-17); evaluate 1.0.5(2025-08-27); fastmap 1.2.0(2024-05-15); fs 1.6.6(2025-04-12); generics 0.1.4(2025-05-09); glue 1.8.0(2024-09-30); hms 1.1.4(2025-10-17); htmltools 0.5.8.1(2024-04-04); httr 1.4.7(2023-08-15); httr2 1.2.1(2025-07-22); igraph 2.2.1(2025-10-27); jsonlite 2.0.0(2025-03-27); knitr 1.50(2025-03-16); later 1.4.4(2025-08-27); lifecycle 1.0.4(2023-11-07); logger 0.4.1(2025-09-11); lubridate 1.9.4(2024-12-08); magrittr 2.0.4(2025-09-12); memoise 2.0.1(2021-11-26); OmnipathR 3.18.0(2025-11-10); otel 0.2.0(2025-08-29); pillar 1.11.1(2025-09-17); pkgconfig 2.0.3(2019-09-22); prettyunits 1.2.0(2023-09-24); processx 3.8.6(2025-02-21); progress 1.2.3(2023-12-06); promises 1.5.0(2025-11-01); ps 1.9.1(2025-04-12); purrr 1.2.0(2025-11-04); R.methodsS3 1.8.2(2022-06-13); R.oo 1.27.1(2025-05-02); R.utils 2.13.0(2025-02-24); R6 2.6.1(2025-02-15); rappdirs 0.3.3(2021-01-31); Rcpp 1.1.0(2025-07-02); readr 2.1.5(2024-01-10); readxl 1.4.5(2025-03-07); rlang 1.1.6(2025-04-11); rmarkdown 2.30(2025-09-28); RSQLite 2.4.4(2025-11-10); rvest 1.0.5(2025-08-29); sessioninfo 1.2.3(2025-02-05); stringi 1.8.7(2025-03-27); stringr 1.6.0(2025-11-04); tibble 3.3.0(2025-06-08); tidyr 1.3.1(2024-01-24); tidyselect 1.2.1(2024-03-11); timechange 0.3.0(2024-01-18); tzdb 0.5.0(2025-03-15); vctrs 0.6.5(2023-12-01); websocket 1.4.4(2025-04-10); withr 3.0.2(2024-10-28); xfun 0.54(2025-10-30); XML 3.99-0.20(2025-11-08); xml2 1.4.1(2025-10-27); yaml 2.3.10(2024-07-26); zip 2.3.3(2025-05-13) [2025-11-10 21:26:52] [INFO] [OmnipathR] CURL: version: 8.14.1; headers: 8.14.1; ssl_version: LibreSSL/3.3.6 (SecureTransport); libz_version: 1.2.11; libssh_version: NA; libidn_version: NA; host: aarch64-apple-darwin23.6.0; protocols: dict, file, ftp, ftps, gopher, gophers, http, https, imap, imaps, ldap, ldaps, mqtt, pop3, pop3s, rtsp, smb, smbs, smtp, smtps, telnet, tftp, ws, wss; ipv6: TRUE; http2: TRUE; idn: FALSE; url_parser: TRUE [2025-11-10 21:26:52] [TRACE] [OmnipathR] Running on a build server, wiping cache. [2025-11-10 21:26:52] [TRACE] [OmnipathR] Cache is at `/Users/biocbuild/Library/Caches/OmnipathR`. [2025-11-10 21:26:52] [TRACE] [OmnipathR] Contains 1 files. [2025-11-10 21:26:52] [TRACE] [OmnipathR] Cache is locked: FALSE. [2025-11-10 21:26:52] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8). [2025-11-10 21:26:52] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:52] [SUCCESS] [OmnipathR] Removing all cache contents from `/Users/biocbuild/Library/Caches/OmnipathR`. [2025-11-10 21:26:52] [TRACE] [OmnipathR] Pandoc version: `3.1.12.3`. [2025-11-10 21:26:52] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/db/db_def.json` (encoding: UTF-8). [2025-11-10 21:26:52] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:52] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/magic_bytes.json` (encoding: UTF-8). [2025-11-10 21:26:52] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:52] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/urls.json` (encoding: UTF-8). [2025-11-10 21:26:52] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:52] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/id_types.json` (encoding: UTF-8). [2025-11-10 21:26:52] [TRACE] [OmnipathR] JSON validation successful: TRUE [2025-11-10 21:26:52] [TRACE] [OmnipathR] Cache locked: FALSE .cosmos_pkn: no visible global function definition for ‘metabolite_idsc’ cosmos_ksn: no visible binding for global variable ‘substrate_genesymbol’ cosmos_ksn: no visible binding for global variable ‘residue_type’ cosmos_ksn: no visible binding for global variable ‘residue_offset’ cosmos_ksn: no visible binding for global variable ‘enzyme_genesymbol’ cosmos_ksn: no visible binding for global variable ‘mor’ recon3d_compartments: no visible global function definition for ‘.slow_dowtest’ recon3d_genes: no visible global function definition for ‘.slow_dowtest’ recon3d_genes: no visible binding for global variable ‘notes’ recon3d_genes: no visible binding for global variable ‘annotation’ recon3d_genes: no visible binding for global variable ‘original_bigg_ids’ recon3d_metabolites: no visible global function definition for ‘.slow_dowtest’ recon3d_metabolites: no visible binding for global variable ‘notes’ recon3d_metabolites: no visible binding for global variable ‘original_bigg_ids’ recon3d_metabolites: no visible binding for global variable ‘annotation’ recon3d_metabolites: no visible binding for global variable ‘hmdb’ recon3d_metabolites: no visible binding for global variable ‘metHMDBID’ recon3d_raw: no visible global function definition for ‘.slow_dowtest’ recon3d_raw_vmh: no visible global function definition for ‘.slow_dowtest’ recon3d_reactions: no visible global function definition for ‘.slow_dowtest’ recon3d_reactions: no visible binding for global variable ‘notes’ recon3d_reactions: no visible binding for global variable ‘metabolites’ recon3d_reactions: no visible binding for global variable ‘original_bigg_ids’ recon3d_table: no visible global function definition for ‘.slow_dowtest’ taxon_names_table: no visible binding for global variable ‘latin_name_uniprot’ taxon_names_table: no visible binding for global variable ‘latin_name_ensembl’ taxon_names_table: no visible binding for global variable ‘latin_name_oma’ taxon_names_table: no visible binding for global variable ‘common_name_ensembl’ taxon_names_table: no visible binding for global variable ‘common_name_uniprot’ Undefined global functions or variables: .slow_dowtest annotation common_name_ensembl common_name_uniprot enzyme_genesymbol hmdb latin_name_ensembl latin_name_oma latin_name_uniprot metHMDBID metabolite_idsc metabolites mor notes original_bigg_ids residue_offset residue_type substrate_genesymbol * checking Rd files ... OK * checking Rd metadata ... OK * checking Rd cross-references ... OK * checking for missing documentation entries ... OK * checking for code/documentation mismatches ... OK * checking Rd \usage sections ... OK * checking Rd contents ... OK * checking for unstated dependencies in examples ... OK * checking R/sysdata.rda ... OK * checking files in ‘vignettes’ ... OK * checking examples ... ERROR Running examples in ‘OmnipathR-Ex.R’ failed The error most likely occurred in: > base::assign(".ptime", proc.time(), pos = "CheckExEnv") > ### Name: recon3d_metabolites > ### Title: Metabolites from Recon-3D > ### Aliases: recon3d_metabolites recon3d_reactions recon3d_genes > ### recon3d_compartments > > ### ** Examples > > recon3d_metabolites() Error in .slow_dowtest() : could not find function ".slow_dowtest" Calls: recon3d_metabolites Execution halted Examples with CPU (user + system) or elapsed time > 5s user system elapsed annotation_categories 37.361 0.034 38.929 curated_ligrec_stats 13.510 1.859 78.408 omnipath-interactions 11.814 0.986 38.040 filter_extra_attrs 8.465 2.854 12.212 extra_attr_values 8.677 1.909 30.652 all_uniprots 6.973 0.716 23.709 go_annot_download 7.010 0.506 10.551 nichenet_gr_network_omnipath 6.059 0.580 8.996 extra_attrs_to_cols 5.198 0.758 6.194 giant_component 4.910 0.518 11.164 nichenet_signaling_network_omnipath 4.295 0.443 7.444 pivot_annotations 4.364 0.288 13.407 omnipath_for_cosmos 4.037 0.242 22.210 has_extra_attrs 2.944 0.841 8.677 filter_by_resource 3.267 0.204 5.765 filter_intercell 3.010 0.203 8.411 curated_ligand_receptor_interactions 2.383 0.397 11.958 print_interactions 2.488 0.179 7.469 ensembl_id_mapping_table 1.509 0.123 17.822 kegg_conv 0.587 0.070 11.153 metalinksdb_sqlite 0.390 0.113 9.594 kinasephos 0.427 0.069 24.062 kegg_link 0.286 0.035 5.225 * checking for unstated dependencies in ‘tests’ ... OK * checking tests ... Running ‘testthat.R’ OK * checking for unstated dependencies in vignettes ... OK * checking package vignettes ... OK * checking running R code from vignettes ... SKIPPED * checking re-building of vignette outputs ... SKIPPED * checking PDF version of manual ... OK * DONE Status: 1 ERROR, 2 NOTEs See ‘/Users/biocbuild/bbs-3.22-bioc/meat/OmnipathR.Rcheck/00check.log’ for details.